Protein Tyrosine Phosphatases, Non-Receptor

Known as: Non Transmembrane Protein Tyrosine Phosphatases, Non-Receptor PTPase, Tyrosine-Protein Phosphatase Non-Receptor Type 
A group of cytosolic enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes… (More)
National Institutes of Health

Related topics

Related topics

22 relations
CytoplasmDephosphorylationEnzyme GeneEsterase Gene
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Narrower (5)

EPM2A protein, humanPTPN14 protein, humanPTPN7 protein, humanSbf2 protein, mouse
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Papers overview

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2017
2017
MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2).
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system, and its pathogenesis remains… (More)
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Highly Cited
2016
Highly Cited
2016
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of… (More)
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Highly Cited
2013
Highly Cited
2013
YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14
The Yes-associated protein (YAP) is a transcriptional factor involved in tissue development and tumorigenesis. Although YAP has… (More)
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2013
2013
Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy
BACKGROUND Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated… (More)
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2012
2012
R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran.
The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase… (More)
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2010
2010
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosine phosphatase that functions… (More)
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2009
2009
The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.
BACKGROUND The lymphoid tyrosine phosphatase (LYP) encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene… (More)
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Highly Cited
1996
Highly Cited
1996
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.
PTP-PEST is a ubiquitously expressed, cytosolic, mammalian protein tyrosine phosphatase (PTP) which exhibits high specific… (More)
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Highly Cited
1996
Highly Cited
1996
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
Cross-linking B cell antigen receptor (BCR) elicits early signal transduction events, including activation of protein tyrosine… (More)
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Highly Cited
1995
Highly Cited
1995
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.
Motheaten viable (mev) mice are deficient in the cytosolic protein tyrosine phosphatase, PTP1C, and exhibit severe B cell… (More)
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