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Protein Tyrosine Phosphatase, Receptor Type B

Known as: VE PTP Phosphatase, Vascular Endothelial Protein Tyrosine Phosphatase, Phosphatase, PTPRB 
National Institutes of Health

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PTPRB gene

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PTPRB protein, human

Papers overview

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2019
2019
VE-PTP phosphatase: a new target for diabetic kidney disease
2018
2018
Targeting the TIE2 pathway with a novel small molecule vascular endothelial protein tyrosine phosphatase (VE-PTP) inhibitor in high-grade serous ovarian cancer
2018
2018
Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR‐377/VE‐PTP axis
The possibility to employ stem/progenitor cells in the cardiovascular remodelling after myocardial infarction is one of the main… 
2017
2017
Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin
Receptor-type protein tyrosine phosphatases (RPTPs) of the R3 subgroup play key roles in the immune, vascular and nervous systems… 
Review
2017
Review
2017
Targeting Tie-2 in patients with wet AMD or diabetic eye disease could allow clinicians to treat patients who have not responded to conventional therapies
The role that VEGF plays in neovascularization and vascular leakage in patients with age-related macular degeneration (AMD) and… 
2015
2015
Characterizing the interaction between VE-PTP , Tie 2 and VE-Cadherin
Many signaling pathways have been shown to be involved in the formation of the vascular system. Among them are the endothelial… 
2015
2015
Endothelial tyrosine kinase receptor B prevents VE-cadherin cleavage and protects against atherosclerotic lesion development in ApoE−/− mice
Tyrosine kinase receptor B (TrkB) is a high-affinity receptor for brain-derived neurotrophic factor (BDNF). In addition to its… 
2014
2014
HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability
Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational… 
2010
2010
Abstract 1560: VE-PTP inhibitor AKB-9778 mitigates IL-2-induced VLS and interacts positively with IL-2 against melanoma and renal cancer tumors in mice
IL-2 induces complete responses (CR) durable more than 10 years in a subpopulation of patients with advanced melanoma or renal… 
2005
2005
Transgenic mouse capable of over-expressing vascular endothelial protein tyrosine phosphatase (ve-ptp)
The present invention relates generally to a transgenic mouse. In particular, the present invention relates to a transgenic mouse… 
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