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Protein Sprouty Homolog 4

Known as: SPRY4, Spry-4 
Protein sprouty homolog 4 (299 aa, ~33 kDa) is encoded by the human SPRY4 gene. This protein plays a role in the inhibition of receptor-mediated… 
National Institutes of Health

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Growth Factor InhibitionSPRY4 geneSignal TransductionSignal Transduction Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
The underlying forces that shape mutational patterns within any type of cancer have been poorly characterized. One of the best… 
2017
2017
Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis
Recent studies have emphasized the important role of long non-coding RNAs (lncRNAs) in cancer development. The present study… 
2017
2017
Abstract LB-307: Dissecting mutual exclusiveness of oncogenic mutations in melanoma
Mutual exclusiveness of oncogenes is a general phenomenon in cancer. Specifically in melanoma BRAF and NRAS mutations do not co… 
2016
2016
SPRY4 Intronic Transcript 1 Promotes Epithelial-Mesenchymal Transition Through Association with Snail1 in Osteosarcoma.
Osteosarcoma is an aggressive tumor and the most common malignancy of the skeleton. Due to pulmonary metastasis, the 5-year… 
2016
2016
Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells
Sprouty (Spry) genes encode inhibitors of the receptor tyrosine kinase signaling cascade, which plays important roles in stem… 
2016
2016
Polymorphisms of KITLG, SPRY4, and BAK1 genes in patients with testicular germ cell tumors and individuals with infertility associated with AZFc deletion of the Y chromosome
Testicular cancer is the most common form of solid cancer in young men. Testicular cancer is represented by testicular germ cell… 
2016
2016
Clinical Impact of KMT2C and SPRY4 Expression Levels in Intensively Treated Younger Adult Acute Myeloid Leukemia Patients
Background: Recent publications suggest important roles of lysine methyltransferase 2C (KMT2C, located on 7q) and sprouty 4… 
2015
2015
MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility
Metastatic melanoma is the deadliest of all skin cancers. Despite progress in diagnostics and treatment of melanoma, the… 
2014
2014
SPRY4-mediated ERK1/2 signaling inhibition abolishes 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell
Abstract Objective: Basic fibroblast growth factor (FGF2)-mediated Extracellular signal-regulated kinases1/2 (ERK1/2) signaling… 
2012
2012
A novel SPRY2 and SPRY4 interaction increases tooth agenesis susceptibility.
Short Communication selected from the Oral Presentations of the 56th Congress of the Groupèment International pour la Recherche… 
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