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Protein Sprouty Homolog 4

Known as: SPRY4, Spry-4 
Protein sprouty homolog 4 (299 aa, ~33 kDa) is encoded by the human SPRY4 gene. This protein plays a role in the inhibition of receptor-mediated… 
National Institutes of Health

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Growth Factor InhibitionSPRY4 geneSignal TransductionSignal Transduction Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP
Lung cancer is one of the most common malignant diseases globally, composed of non-small cell lung cancer (NSCLC, 85%) and small… 
Highly Cited
2016
Highly Cited
2016
H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma
Abstract Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. In… 
Highly Cited
2016
Highly Cited
2016
Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer.
UNLABELLED KRAS is frequently mutated in lung cancer. Whereas MAPK is a well-known effector pathway of KRAS, blocking this… 
Highly Cited
2016
Highly Cited
2016
Potential diagnostic value of lncRNA SPRY4-IT1 in hepatocellular carcinoma.
The manifestation of hepatocellular carcinoma (HCC) involves a multi-factor, multi-step and complex process. Due to the lack of… 
Highly Cited
2015
Highly Cited
2015
Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer
Gastric cancer (GC) is the second common cause of cancer-related death worldwide. Long noncoding RNAs (lncRNAs) are emerging as… 
Highly Cited
2014
Highly Cited
2014
EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial–mesenchymal transition
Recent evidence indicates that long noncoding RNAs (lncRNAs) have a critical role in the regulation of cellular processes such as… 
Highly Cited
2007
Highly Cited
2007
An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
Rodent incisors grow throughout adult life, but are prevented from becoming excessively long by constant abrasion, which is… 
Highly Cited
2006
Highly Cited
2006
A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation*
Because the Sprouty (Spry) proteins were shown to be inhibitors of the mainstream Ras/ERK pathway, there has been considerable… 
Highly Cited
2004
Highly Cited
2004
SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type BRAF but Not with the V599E Mutant
BRAF mutations result in constitutively active BRAF kinase activity and increased extracellular signal-regulated kinase (ERK… 
Highly Cited
2001
Highly Cited
2001
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish
analysis reveals that signaling through FGFR1/Ras/mitogen-activated protein kinase pathway is involved, not in mesoderm induction… 
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