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The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a… Expand Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative… Expand Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a… Expand The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major source of calcium (Ca2… Expand Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are… Expand The FKBP12-rapamycin-associated protein (FRAP; also called RAFT1/mTOR) regulates translation initiation and entry into the cell… Expand Protein phosphorylation plays a cardinal role in regulating many cellular processes in eukaryotes. In particular, protein… Expand LONG-TERM potentiation (LTP) is a synaptic mechanism thought to be involved in learning and memory1. Long-term depression (LTD… Expand Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat brain. Ceramide-activated protein… Expand We have purified the 36 and 63 kd cellular proteins known to associate with polyomavirus middle and small tumor (T) antigens and… Expand