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Prostaglandin E Synthase 2, human

Known as: Microsomal Prostaglandin E Synthase 2, EC 5.3.99.3, Membrane-Associated Prostaglandin E Synthase 2 
Prostaglandin E synthase 2 (377 aa, ~42 kDa) is encoded by the human PTGES2 gene. This protein plays a role in both the synthesis of prostaglandin E2… 
National Institutes of Health

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Arachidonic Acid Metabolism PathwayEnzyme GenePTGES2 geneProstaglandin E Synthase, human

Papers overview

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Review
2010
Review
2010
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.
Highly Cited
2009
Highly Cited
2009
The terminal prostaglandin synthases mPGES‐1, mPGES‐2, and cPGES are all overexpressed in human gliomas
Prostaglandin E2 has been connected to processes promoting tumor growth in several human malignancies including gliomas. The… 
Highly Cited
2007
Highly Cited
2007
Prostaglandin metabolism in human hair follicle
Abstract:  Prostaglandins regulate a wide number of physiological functions. Recently PGF2α analogue such as latanoprost was… 
Review
2006
Review
2006
Prostaglandin E synthase: a novel drug target for inflammation and cancer.
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H(2) to PGE(2), occurs in… 
Highly Cited
2005
Highly Cited
2005
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Review
2005
Review
2005
Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis.
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase… 
Highly Cited
2005
Highly Cited
2005
Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).
Highly Cited
2005
Highly Cited
2005
Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue
Recently, three different prostaglandin E2 synthases have been identified: microsomal prostaglandin E synthase (mPGES)-1… 
Highly Cited
2003
Highly Cited
2003
Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2*
Current evidence suggests that two forms of prostaglandin (PG) E synthase (PGES), cytosolic PGES and membrane-bound PGES (mPGES… 
Highly Cited
2003
Highly Cited
2003
Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis…
To better define the role of the various prostanoid synthases in the adjuvant-induced arthritis (AIA) model, we have determined… 
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