Prodrugs

Known as: Pro-Drugs, prodrug, Pro Drugs 
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and… (More)
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Highly Cited
2010
Highly Cited
2010
Anticancer drugs embedded in or conjugated with inert nanocarriers, referred to as nanomedicines, show many therapeutic… (More)
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Review
2008
Review
2008
Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to… (More)
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Highly Cited
2008
Highly Cited
2008
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In… (More)
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Review
2008
Review
2008
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of… (More)
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Highly Cited
2008
Highly Cited
2008
PTEN and the pan phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1 benzopyran-4-one (LY294002) exert… (More)
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Highly Cited
2008
Highly Cited
2008
Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its… (More)
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Highly Cited
2007
Highly Cited
2007
Human adipose tissue-derived mesenchymal stem cells (AT-MSC) are considered to be a promising source of autologous stem cells in… (More)
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Review
2004
Review
2004
Solid tumours contain regions at very low oxygen concentrations (hypoxia), often surrounding areas of necrosis. The cells in… (More)
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Highly Cited
2002
Highly Cited
2002
FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanism of inhibition of which has been unknown. Here we show… (More)
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