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Procaspase Activating Compound-1 VO-100

Known as: PAC-1, PAC-1 VO-100, VO-100 
An orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

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2018
2018
The e ff ects of storage on platelet function in di ff erent blood products
Objectives: Reduced platelet (PLT) function during storage has been shown for buffy-coatderived platelet concentrates (BCP) and… 
2013
2013
Nanoparticles and atherosclerosis : resolving the paradox
......................................................................................................... 54 2.1 Nanoparticle… 
2010
2010
[The study of relationship between platelet function and thrombus in patients with essential thrombocythaemia].
OBJECTIVE To observe the influence of the plasma thromboxane B2 (TXB2), 6-keto-PGF1alpha, CD62P and PAC-1 and Thrombus in… 
2010
2010
Initial observation of dipyridamole influence on PAC-1 and CD62p expressions in lymphoma patients
OBJECTIVE:To study the influence of dipyridamole on the expressions of platelet activated markers PAC-1 and CD62p and the short… 
2009
2009
Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation
Platelets are activated in vivo by multiple agonists; however, platelet function testing in vitro has been performed… 
2008
2008
Ligand-mimetic anti-aIIbβ3 antibody PAC-1 inhibits tyrosine signaling, proliferation and lung colonization of melanoma cells
Abstractβ3 integrin expression is the hallmark of melanoma and may serve as a potential therapeutic target. While αvβ3 integrin… 
2005
2005
New Insights into the Catalytic Activation of the MAPK Phosphatase PAC-1 Induced by its Substrate MAPK ERK 2 Binding
0022-2836/$ see front matter q 2005 E Abbreviations used: ERK, extrace regulated kinase; GST, glutathionec-Jun NH2-terminal… 
2005
2005
[Study on platelet activated state and platelet activated function in adults with acute leukemia].
To investigate the changes of platelet activated state and platelet activated function by trace whole blood flow cytometry (FCM… 
2004
2004
Comparison for the expression of PAC-1 and CD62p on platelet microparticles (PMP) by activating platelet with different agonists
Objective To compare the expression percentage of PAC-1 and CD62p on platelet microparticles (PMP) by using different agonists to… 
1999
1999
[Detection of activated platelets by flow cytometry].
While bleeding time and platelet aggregometry are the two standard clinical tests of platelet function, an increasing number of…