Procaspase Activating Compound-1 VO-100

Known as: PAC-1, PAC-1 VO-100, VO-100 
An orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Mutation and aberrant expression of apoptotic proteins are hallmarks of cancer. These changes prevent proapoptotic signals from… (More)
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Highly Cited
2006
Highly Cited
2006
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND AIM OF THE STUDY In tissue engineering of heart valves using decellularized xenogenic valves, it has been… (More)
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Highly Cited
2005
Highly Cited
2005
Residues important in the interaction between the 23-residue transmembrane (TM) domains of the integrin alpha(IIb)- and beta(3… (More)
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Highly Cited
2003
Highly Cited
2003
Formation of platelet-leukocyte aggregates via the CD62 ligand represents an important mechanism by which leukocytes contribute… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Platelet activation plays an important role in arterial thrombosis and the widespread use of aspirin has reduced major… (More)
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Highly Cited
2001
Highly Cited
2001
It is possible that platelet activation may play a pathogenic role in the increased risk of thrombosis associated with… (More)
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Highly Cited
2000
Highly Cited
2000
There is speculation that dietary polyphenols can provide cardioprotective effects due to direct antioxidant or antithrombotic… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The growing use of heparin in acute thrombotic disorders, coupled with the availability of many new antithrombotic… (More)
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Highly Cited
1985
Highly Cited
1985
Platelet activation is accompanied by the appearance on the platelet surface of approximately 45,000 receptor sites for… (More)
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