Probable Methylcytosine Dioxygenase TET2

Known as: EC 1.14.11.n2, Methylcytosine Dioxygenase TET2, TET2 
Methylcytosine dioxygenase TET2 (2002 aa, ~224 kDa) is encoded by the human TET2 gene. This protein is involved in methylcytosine oxidation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
010020020012017

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations… (More)
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Highly Cited
2014
Highly Cited
2014
High-throughput DNA sequencing significantly contributed to diagnosis and prognostication in patients with myelodysplastic… (More)
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Highly Cited
2014
Highly Cited
2014
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without… (More)
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Highly Cited
2012
Highly Cited
2012
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and… (More)
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Highly Cited
2011
Highly Cited
2011
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients… (More)
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Highly Cited
2011
Highly Cited
2011
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2 gene have been described in… (More)
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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… (More)
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Highly Cited
2010
Highly Cited
2010
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The… (More)
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Highly Cited
2009
Highly Cited
2009
To the Editor: The finding of Delhommeau and colleagues that TET2 mutations occur in myeloid cancers (May 28 issue)1 has been… (More)
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Highly Cited
2009
Highly Cited
2009
Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent… (More)
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