Prexasertib

Known as: 2-Pyrazinecarbonitrile, 5-((5-(2-(3-Aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)- 
An inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, prexasertib selectively binds to chk1… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2016-2018
02420162018

Papers overview

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2018
2018
PURPOSE Prexasertib, a checkpoint kinase 1 inhibitor, demonstrated single-agent activity in patients with advanced squamous cell… (More)
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2018
2018
LC MS/MS methods to measure prexasertib in mouse plasma and Ringer's solution containing 0.5% BSA (Ringer's/BSA) were developed… (More)
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2018
2018
BACKGROUND High-grade serous ovarian carcinoma is characterised by TP53 mutations, DNA repair defects, and genomic instability… (More)
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2018
2018
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress… (More)
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2017
2017
Purpose: Checkpoint kinase 1 (CHK1) is a key regulator of the DNA damage response and a mediator of replication stress through… (More)
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2017
2017
Effective targeted therapies for small-cell lung cancer (SCLC), the most aggressive form of lung cancer, remain urgently needed… (More)
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2017
2017
Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional… (More)
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2017
2017
2017
EGFR inhibition and radiotherapy are potent inducers of DNA damage. Checkpoint kinases 1 and 2 (Chk1/2) are critical regulators… (More)
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2016
2016
During the last few years many Checkpoint kinase 1/2 (Chk1/Chk2) inhibitors have been developed for the treatment of different… (More)
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