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Praziquantel

Known as: 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, Prasiquantel, Praziquantel [Chemical/Ingredient] 
A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms… Expand
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (12)

4-hydroxypraziquantel8-hydroxypraziquantelBiltricideCesol
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Broader (1)

Anthelmintics
ClonorchiasisCysticercosisDrug AllergyHelminthiasis
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel… Expand
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Highly Cited
2009
Highly Cited
2009
Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni
Background The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the… Expand
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Review
2007
Review
2007
Liver Fluke Induces Cholangiocarcinoma
The authors discuss the molecular pathogenesis of opisthorchiasis and associated cholangiocarcinogenesis, particularly nitrative… Expand
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Review
2006
Review
2006
Human schistosomiasis
Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. The transmission cycle requires… Expand
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Highly Cited
2005
Highly Cited
2005
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical… Expand
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Highly Cited
2004
Highly Cited
2004
Praziquantel, a new broad-spectrum antischistosomal agent
SummaryPraziquantel, (2-cyclohexylcarbonyl)-1,2,3,6,7,11b-hexa-hydro-2H pyrazino[2,1a]isoquinolin-4-one, belongs to a new series… Expand
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Highly Cited
2004
Highly Cited
2004
Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment.
The efficacy of praziquantel against a Puerto Rican strain of Schistosoma mansoni was assessed using both in vivo and in vitro… Expand
Highly Cited
1996
Highly Cited
1996
Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.
To determine if resistance/tolerance to the antischistosomal drug praziquantel (PZQ) is appearing in Egyptian villages within the… Expand
Highly Cited
1995
Highly Cited
1995
Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni.
Schistosoma mansoni was first reported in the area of Richard Toll (Senegal) in 1988 and spread rapidly in the community, after a… Expand
Highly Cited
1994
Highly Cited
1994
Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.
Schistosoma mansoni infections in mice were treated with subcurative multiple doses of either praziquantel (PZQ) or oxamniquine… Expand
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