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Praziquantel
Known as:
4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
, Prasiquantel
, Praziquantel [Chemical/Ingredient]
A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms…
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National Institutes of Health
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Related topics
Related topics
39 relations
Narrower (12)
4-hydroxypraziquantel
8-hydroxypraziquantel
Biltricide
Cesol
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Broader (1)
Anthelmintics
Clonorchiasis
Cysticercosis
Drug Allergy
Helminthiasis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules
M. Gouveia
,
P. Brindley
,
F. Gärtner
,
J. C. D. da Costa
,
N. Vale
Pharmaceuticals
2018
Corpus ID: 4565694
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel…
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Highly Cited
2009
Highly Cited
2009
Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni
S. Melman
,
M. L. Steinauer
,
+10 authors
E. Loker
PLoS neglected tropical diseases
2009
Corpus ID: 13919050
Background The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the…
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Review
2007
Review
2007
Liver Fluke Induces Cholangiocarcinoma
B. Sripa
,
S. Kaewkes
,
+10 authors
P. Brindley
PLoS medicine
2007
Corpus ID: 2620314
The authors discuss the molecular pathogenesis of opisthorchiasis and associated cholangiocarcinogenesis, particularly nitrative…
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Review
2006
Review
2006
Human schistosomiasis
B. Gryseels
,
K. Polman
,
J. Clerinx
,
L. Kestens
The Lancet
2006
Corpus ID: 999943
Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. The transmission cycle requires…
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Highly Cited
2005
Highly Cited
2005
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
R. Mainardes
,
R. C. Evangelista
International journal of pharmaceutics
2005
Corpus ID: 2009254
Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical…
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Highly Cited
2004
Highly Cited
2004
Praziquantel, a new broad-spectrum antischistosomal agent
R. Gönnert
,
P. Andrews
Zeitschrift für Parasitenkunde
2004
Corpus ID: 187320
SummaryPraziquantel, (2-cyclohexylcarbonyl)-1,2,3,6,7,11b-hexa-hydro-2H pyrazino[2,1a]isoquinolin-4-one, belongs to a new series…
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Highly Cited
2004
Highly Cited
2004
Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment.
L. Pica-Mattoccia
,
D. Cioli
International journal for parasitology
2004
Corpus ID: 31874172
The efficacy of praziquantel against a Puerto Rican strain of Schistosoma mansoni was assessed using both in vivo and in vitro…
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Highly Cited
1996
Highly Cited
1996
Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.
M. Ismail
,
A. Metwally
,
A. Farghaly
,
J. Bruce
,
L. F. Tao
,
J. L. Bennett
The American journal of tropical medicine and…
1996
Corpus ID: 21809734
To determine if resistance/tolerance to the antischistosomal drug praziquantel (PZQ) is appearing in Egyptian villages within the…
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Highly Cited
1995
Highly Cited
1995
Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni.
F. Stelma
,
I. Talla
,
+5 authors
B. Gryseels
The American journal of tropical medicine and…
1995
Corpus ID: 9124987
Schistosoma mansoni was first reported in the area of Richard Toll (Senegal) in 1988 and spread rapidly in the community, after a…
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Highly Cited
1994
Highly Cited
1994
Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.
P. Fallon
,
M. Doenhoff
The American journal of tropical medicine and…
1994
Corpus ID: 9478650
Schistosoma mansoni infections in mice were treated with subcurative multiple doses of either praziquantel (PZQ) or oxamniquine…
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