Praziquantel

Known as: 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, Prasiquantel, Praziquantel [Chemical/Ingredient] 
A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms… (More)
National Institutes of Health

Related topics

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35 relations

Narrower (12)

4-hydroxypraziquantel8-hydroxypraziquantelBiltricideCesol
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Broader (1)

Anthelmintics
ClonorchiasisCysticercosisDrug AllergyHelminthiasis
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Papers overview

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Review
2014
Review
2014
Schistosomiasis control: praziquantel forever?
Since no vaccine exists against schistosomiasis and the molluscs acting as intermediate hosts are not easy to attack… (More)
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Highly Cited
2009
Highly Cited
2009
Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni
BACKGROUND The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the… (More)
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Review
2006
Review
2006
Human schistosomiasis
Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma. The transmission cycle requires… (More)
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Highly Cited
2005
Highly Cited
2005
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical… (More)
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Highly Cited
2004
Highly Cited
2004
Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment.
The efficacy of praziquantel against a Puerto Rican strain of Schistosoma mansoni was assessed using both in vivo and in vitro… (More)
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Review
2002
Review
2002
Resistance of Schistosoma mansoni to praziquantel: is there a problem?
Evidence for resistance to praziquantel (PZQ) in Schistosoma mansoni has been sought in parasites taken from treated, but uncured… (More)
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Review
2001
Review
2001
Proposed diagnostic criteria for neurocysticercosis.
Neurocysticercosis is the most common helminthic infection of the CNS but its diagnosis remains difficult. Clinical… (More)
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Highly Cited
1996
Highly Cited
1996
Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel.
To determine if resistance/tolerance to the antischistosomal drug praziquantel (PZQ) is appearing in Egyptian villages within the… (More)
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Highly Cited
1994
Highly Cited
1994
Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.
Schistosoma mansoni infections in mice were treated with subcurative multiple doses of either praziquantel (PZQ) or oxamniquine… (More)
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Highly Cited
1977
Highly Cited
1977
Praziquantel, a new broad-spectrum antischistosomal agent
Praziquantel, (2-cyclohexylcarbonyl)-1,2,3,6,7,11b-hexa-hydro-2H pyrazino[2,1a]isoquinolin-4-one, belongs to a new series of… (More)
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