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Positive Transcriptional Elongation Factor B

Known as: tat Associated Kinase, P-TEFb, tat-Associated Kinase 
A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

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pgc protein, Drosophila

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma
The role of the positive RNA Pol II regulator, P-TEFb (positive transcription elongation factor b), in maintenance of the anti… 
2010
2010
Myc Regulation of mRNA Cap Methylation.
The c-myc proto-oncogene regulates the expression of 15% to 20% of all genes, depending on the cell type, and the regulation is… 
2009
2009
Dysregulation of positive transcription elongation factor B and myocardial hypertrophy.
See related articles, pages 1347–1354 Prolonged stimulus of the adult heart by hypertension, arrhythmias, or other pathogenic… 
2007
2007
Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.
2006
2006
Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of… 
2005
2005
Runx1 Binds Positive Transcription Elongation Factor b and Represses Transcriptional Elongation by RNA Polymerase II: Possible Mechanism of CD4 Silencing
ABSTRACT Runx1 binds the silencer and represses CD4 transcription in immature thymocytes. In this study, we found that Runx1… 
2005
2005
Artificial Zinc Finger Fusions Targeting Sp1-binding Sites and the trans-Activator-responsive Element Potently Repress Transcription and Replication of HIV-1*
Tat activates transcription by interacting with Sp1, NF-κB, positive transcription elongation factor b, and trans-activator… 
2004
2004
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.
2000
2000
Genomic organization and characterization of promoter function of the human CDK9 gene.
Highly Cited
1999
Highly Cited
1999
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
HIV-1 gene expression and viral replication require the viral transactivator protein Tat. The RNA polymerase II transcriptional… 
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