Polypharmacology

The design or use of pharmaceutical agents that act on multiple targets or disease pathways.
National Institutes of Health

Papers overview

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2016
2016
Promising promiscuity: Guest editors Maria Laura Bolognesi and Andrea Cavalli set the stage for this ChemMedChem Special Issue on… (More)
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Review
2016
Review
2016
Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these… (More)
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2015
2015
In the last years, the " one target, one drug " paradigm that has traditionally dominated drug discovery has been deeply… (More)
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2014
2014
Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately… (More)
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2012
2012
Polypharmacology has emerged as a new theme in drug discovery. In this paper, we studied polypharmacology using a ligand-based… (More)
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2012
2012
Most drugs exert their effects via multitarget interactions, as hypothesized by polypharmacology. While these multitarget… (More)
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Review
2012
Review
2012
Polypharmacology-based strategies are gaining increased attention as a novel approach to obtaining potentially innovative… (More)
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2010
2010
Polypharmacology is receiving increasing attention in the pharmaceutical industry, since finding new targets of a compound is… (More)
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Review
2010
Review
2010
Many successful drugs bind to and modulate multiple targets in vivo. Successfully navigating protein-ligand polypharmacology will… (More)
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2009
2009
The association between molecular size and risk of failure has promoted the use of binding efficiency as a prioritization metric… (More)
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