Polynucleotide 5'-Hydroxyl-Kinase

Known as: ATP:5'-dephosphopolynucleotide 5'-phosphotransferase, Kinase, DNA, Polynucleotide Hydroxylkinase 
An enzyme that catalyzes the transfer of a phosphate group to the 5'-terminal hydroxyl groups of DNA and RNA. EC 2.7.1.78.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1950-2017
0102019502016

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Highly Cited
2008
Highly Cited
2008
The exosome is a major eukaryotic nuclease located in both the nucleus and the cytoplasm that contributes to the processing… (More)
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Highly Cited
2005
Highly Cited
2005
Mammalian polynucleotide kinase (PNK) is a key component of both the base excision repair (BER) and nonhomologous end-joining… (More)
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Highly Cited
2004
Highly Cited
2004
Nonhomologous end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammalian cells. A critical step in… (More)
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Highly Cited
2004
Highly Cited
2004
The paradigm for repair of oxidized base lesions in genomes via the base excision repair (BER) pathway is based on studies in… (More)
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Highly Cited
2003
Highly Cited
2003
DNA topoisomerase I (Top1) is converted into a cellular poison by camptothecin (CPT) and various endogenous and exogenous DNA… (More)
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Highly Cited
1995
Highly Cited
1995
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin… (More)
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Highly Cited
1994
Highly Cited
1994
We have isolated a large number of polynucleotide kinase ribozymes from a pool of RNA molecules consisting of an ATP-binding… (More)
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Highly Cited
1985
Highly Cited
1985
We have previously described a 32P assay for the detection and quantitation of aromatic carcinogen:DNA adducts (R. C. Gupta et al… (More)
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Highly Cited
1982
Highly Cited
1982
A newly developed enzymatic 32P-postlabeling method was applied to the analysis of DNA's containing non-radioactive arylamine… (More)
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Highly Cited
1981
Highly Cited
1981
Covalent adducts formed by the reaction of DNA with chemical carcinogens and mutagens may be detected by a 32P-labeling test. DNA… (More)
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