Polyamine Analogue

A compound that mimics the naturally occurring polyamines but is modified in such a way that its function differs from that of the natural polyamines… (More)
National Institutes of Health

Papers overview

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2010
2010
Bleomycin is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas, and… (More)
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Highly Cited
2005
Highly Cited
2005
The induction of polyamine catabolism and its production of H2O2 have been implicated in the response to specific antitumor… (More)
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Review
2001
Review
2001
  • T J Thomas
  • Cellular and Molecular Life Sciences CMLS
  • 2001
Polyamines are aliphatic cations with multiple functions and are essential for life. Cellular polyamine levels are regulated by… (More)
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Highly Cited
2001
Highly Cited
2001
Mammalian polyamine catabolism is under the control of two enzymes, spermidine/spermine N1-acetyltransferase and the flavin… (More)
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Highly Cited
2001
Highly Cited
2001
N(1),N(11)-Diethylnorspermine (DENSPM) is a polyamine analogue with clinicalrelevance as an experimental anticancer agent and the… (More)
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1999
1999
We recently generated a transgenic mouse line overexpressing spermidine/spermine N1-acetyltransferase (SSAT) gene under its own… (More)
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Highly Cited
1997
Highly Cited
1997
N1-ethyl-N11-[(cyclopropyl)methyl]-4,8,-diazaundecane (CPENSpm) is a polyamine analogue that represents a new class of antitumor… (More)
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1995
1995
The need for antineoplastic compounds with novel mechanisms of action is great. One such agent is the recently synthesized… (More)
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1995
1995
Certain N-alkylated analogues of the natural polyamine spermine have been found to disrupt polyamine pool homeostasis and inhibit… (More)
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Highly Cited
1991
Highly Cited
1991
The polyamine analogue, N1,N12-bis(ethyl(-spermine (BESPM), is known to suppress ornithine and S-adenosylmethionine decarboxylase… (More)
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