FAQ

Poly(ADP-ribose) Polymerases

Known as: Poly(ADP-Ribose) Synthase, Poly(ADPribose) Polymerase, NAD(+) ADP ribosyltransferase 
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up… (More)

Topic mentions per year

Topic mentions per year

1968-2017
0204019682017

Related topics

Related topics

21 relations
ADP Ribose TransferasesAdenine PhosphoribosyltransferaseIn BloodMono(ADP-Ribose) Transferases
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Narrower (3)

PARP1 protein, humanPARP2 protein, humanTiPARP protein, human

Broader (1)

pentosyltransferase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Poly(ADP-ribose) Polymerases
physiological aspects
chemical synthesis
PARP1 protein, human
Adenine Phosphoribosyltransferase
PARP1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing
Understanding the structure-function relationships at cellular, circuit, and organ-wide scale requires 3D anatomical and… (More)
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2012
2012
Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes*
Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear protein that binds chromatin and catalyzes the transfer of ADP… (More)
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Highly Cited
2010
Highly Cited
2010
Genome-wide measurement of RNA secondary structure in yeast.
The structures of RNA molecules are often important for their function and regulation, yet there are no experimental techniques… (More)
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Highly Cited
2006
Highly Cited
2006
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage… (More)
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2001
2001
Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.
Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to cardiac dysfunction, in part, via the… (More)
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Highly Cited
2000
Highly Cited
2000
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
BACKGROUND The generation of reactive oxygen species (ROS) contributes to the pathogenesis of renal ischemia-reperfusion injury… (More)
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Highly Cited
1998
Highly Cited
1998
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.
Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated… (More)
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Highly Cited
1998
Highly Cited
1998
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
The nuclear enzyme poly (ADP-ribose) synthetase (PARS) has been shown to play an important role in the pathogenesis of ischemia… (More)
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Highly Cited
1996
Highly Cited
1996
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.
The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo… (More)
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Highly Cited
1994
Highly Cited
1994
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.
Poly(adenosine 5'-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when activated by DNA strand breaks, adds up to… (More)
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