Poly(ADP-ribose) Polymerases

Known as: Poly(ADP-Ribose) Synthase, Poly(ADPribose) Polymerase, NAD(+) ADP ribosyltransferase 
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up… (More)

Topic mentions per year

Topic mentions per year

1968-2017
0204019682017

Papers overview

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Highly Cited
2014
Highly Cited
2014
Understanding the structure-function relationships at cellular, circuit, and organ-wide scale requires 3D anatomical and… (More)
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2012
2012
Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear protein that binds chromatin and catalyzes the transfer of ADP… (More)
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Highly Cited
2010
Highly Cited
2010
The structures of RNA molecules are often important for their function and regulation, yet there are no experimental techniques… (More)
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Highly Cited
2006
Highly Cited
2006
Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage… (More)
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2001
2001
Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to cardiac dysfunction, in part, via the… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The generation of reactive oxygen species (ROS) contributes to the pathogenesis of renal ischemia-reperfusion injury… (More)
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Highly Cited
1998
Highly Cited
1998
Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated… (More)
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Highly Cited
1998
Highly Cited
1998
The nuclear enzyme poly (ADP-ribose) synthetase (PARS) has been shown to play an important role in the pathogenesis of ischemia… (More)
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Highly Cited
1996
Highly Cited
1996
The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo… (More)
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Highly Cited
1994
Highly Cited
1994
Poly(adenosine 5'-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when activated by DNA strand breaks, adds up to… (More)
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