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Poly(ADP-ribose) Polymerase Inhibitors
Known as:
Poly (ADP-Ribose) Polymerase Inhibitor
, PARP Inhibitors
, PARP inhibitor
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A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell…
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National Institutes of Health
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22 relations
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1,5-dihydroisoquinoline
1,5-dihydroxyisoquinoline
3-aminobenzamide
3-methoxybenzamide
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In Blood
PARP1 protein, human
Poly(ADP-Ribose) Polymerase Inhibitor [EPC]
Poly(ADP-Ribose) Polymerase Inhibitors [MoA]
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others.
Ying Chen
,
Hui Du
Biomedicine & pharmacotherapy = Biomedecine…
2018
Corpus ID: 48356688
2017
2017
A phase II study of the anti-programmed death ligand-1 antibody durvalumab (D; MEDI4736) in combination with PARP inhibitor, olaparib (O), in metastatic castration-resistant prostate cancer (mCRPC).
F. Karzai
,
R. Madan
,
+13 authors
Jung-Min Lee
2017
Corpus ID: 78972849
162Background: Recent data suggests 25-30% of sporadic mCRPC has defects in DNA repair pathways which may confer sensitivity to…
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Review
2017
Review
2017
PARP inhibitors as antitumor agents: a patent update (2013-2015)
Zigao Yuan
,
Jiwei Chen
,
+4 authors
Yuyang Jiang
Expert Opinion on Therapeutic Patents
2017
Corpus ID: 205767601
ABSTRACT Introduction: PARP inhibitors have been extensively explored as antitumor agents and have shown potent efficacy both in…
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Review
2011
Review
2011
PARP inhibitors--current status and the walk towards early breast cancer.
J. Glendenning
,
A. Tutt
Breast
2011
Corpus ID: 3337985
Review
2010
Review
2010
DNA repair pathways and their implication in cancer treatment
A. Pallis
,
M. Karamouzis
Cancer Metastasis Review
2010
Corpus ID: 39553672
Many cytotoxic agents used in cancer treatment exert their effects through their ability to directly or indirectly damage DNA and…
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2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
S. Kyle
,
Huw D. Thomas
,
J. Mitchell
,
N. Curtin
British Journal of Radiology
2008
Corpus ID: 5092543
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability…
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2005
2005
Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.
M. Kendirci
,
Z. Zsengellér
,
+5 authors
W. Hellstrom
Journal of Urology
2005
Corpus ID: 23232859
PURPOSE We investigated the involvement of poly(adenosine diphosphate-ribose) (PAR) polymerase (PARP) activation in the…
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Review
2004
Review
2004
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.
H. Bryant
,
T. Helleday
Biochemical Society Transactions
2004
Corpus ID: 8476353
PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair…
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1999
1999
Biochemical characterization of mono(ADP-ribosyl)ated poly(ADP-ribose) polymerase.
H. Mendoza-Alvarez
,
R. Alvarez‐Gonzalez
Biochemistry
1999
Corpus ID: 25503058
Here, we report the biochemical characterization of mono(ADP-ribosyl)ated poly(ADP-ribose) polymerase (PARP) (EC 2.4.2. 30). PARP…
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1997
1997
Detection of DNA breaks in apoptotic cells utilizing the DNA binding domain of poly(ADP-ribose) polymerase with fluorescence microscopy.
D. Rosenthal
,
R. Ding
,
C. Simbulan-Rosenthal
,
B. Cherney
,
P. Vanek
,
M. Smulson
Nucleic Acids Research
1997
Corpus ID: 8742752
The DNA binding domain (DBD) of poly(ADP-ribose) polymerase (PARP) has proved to be a novel, highly sensitive probe for detecting…
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