Skip to search formSkip to main contentSkip to account menu

Poly(ADP-ribose) Polymerase Inhibitors

Known as: Poly (ADP-Ribose) Polymerase Inhibitor, PARP Inhibitors, PARP inhibitor 
A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell… 
National Institutes of Health

Related topics

Related topics

22 relations

Narrower (15)

1,5-dihydroisoquinoline1,5-dihydroxyisoquinoline3-aminobenzamide3-methoxybenzamide
In BloodPARP1 protein, humanPoly(ADP-Ribose) Polymerase Inhibitor [EPC]Poly(ADP-Ribose) Polymerase Inhibitors [MoA]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others.
  • Ying ChenHui Du
  • Biomedicine & pharmacotherapy = Biomedecine…
  • 2018
  • Corpus ID: 48356688
2017
2017
A phase II study of the anti-programmed death ligand-1 antibody durvalumab (D; MEDI4736) in combination with PARP inhibitor, olaparib (O), in metastatic castration-resistant prostate cancer (mCRPC).
162Background: Recent data suggests 25-30% of sporadic mCRPC has defects in DNA repair pathways which may confer sensitivity to… 
Review
2017
Review
2017
PARP inhibitors as antitumor agents: a patent update (2013-2015)
ABSTRACT Introduction: PARP inhibitors have been extensively explored as antitumor agents and have shown potent efficacy both in… 
Review
2011
Review
2011
PARP inhibitors--current status and the walk towards early breast cancer.
Review
2010
Review
2010
DNA repair pathways and their implication in cancer treatment
Many cytotoxic agents used in cancer treatment exert their effects through their ability to directly or indirectly damage DNA and… 
2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability… 
2005
2005
Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury.
PURPOSE We investigated the involvement of poly(adenosine diphosphate-ribose) (PAR) polymerase (PARP) activation in the… 
Review
2004
Review
2004
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.
PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair… 
1999
1999
Biochemical characterization of mono(ADP-ribosyl)ated poly(ADP-ribose) polymerase.
Here, we report the biochemical characterization of mono(ADP-ribosyl)ated poly(ADP-ribose) polymerase (PARP) (EC 2.4.2. 30). PARP… 
1997
1997
Detection of DNA breaks in apoptotic cells utilizing the DNA binding domain of poly(ADP-ribose) polymerase with fluorescence microscopy.
The DNA binding domain (DBD) of poly(ADP-ribose) polymerase (PARP) has proved to be a novel, highly sensitive probe for detecting… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)