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Poly(ADP-ribose) Polymerase Inhibitors

Known as: Poly (ADP-Ribose) Polymerase Inhibitor, PARP Inhibitors, PARP inhibitor 
A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell… 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
  • Ying ChenHui Du
  • 2018
  • Corpus ID: 48356688
2017
2017
162Background: Recent data suggests 25-30% of sporadic mCRPC has defects in DNA repair pathways which may confer sensitivity to… 
Review
2017
Review
2017
ABSTRACT Introduction: PARP inhibitors have been extensively explored as antitumor agents and have shown potent efficacy both in… 
Review
2010
Review
2010
Many cytotoxic agents used in cancer treatment exert their effects through their ability to directly or indirectly damage DNA and… 
2008
2008
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability… 
2005
2005
PURPOSE We investigated the involvement of poly(adenosine diphosphate-ribose) (PAR) polymerase (PARP) activation in the… 
Review
2004
Review
2004
PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair… 
1999
1999
Here, we report the biochemical characterization of mono(ADP-ribosyl)ated poly(ADP-ribose) polymerase (PARP) (EC 2.4.2. 30). PARP… 
1997
1997
The DNA binding domain (DBD) of poly(ADP-ribose) polymerase (PARP) has proved to be a novel, highly sensitive probe for detecting…