Poly(ADP-ribose) Polymerase Inhibitors

Known as: Poly (ADP-Ribose) Polymerase Inhibitor, PARP Inhibitors, PARP inhibitor 
A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell… (More)

Topic mentions per year

Topic mentions per year

1986-2017
05010015019862017

Papers overview

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Highly Cited
2012
Highly Cited
2012
PURPOSE Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Selective tumor cell cytotoxicity can be achieved through a synthetic lethal strategy using poly(ADP)-ribose polymerase… (More)
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Highly Cited
2010
Highly Cited
2010
Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB) or at stalled replication forks to… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE We conducted the first phase 0 clinical trial in oncology of a therapeutic agent under the Exploratory Investigational… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE One mechanism of tumor resistance to cytotoxic therapy is repair of damaged DNA. Poly(ADP-ribose) polymerase (PARP)-1 is… (More)
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Highly Cited
2007
Highly Cited
2007
Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks… (More)
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Highly Cited
2006
Highly Cited
2006
Poly (ADP-ribose) polymerase (PARP-1), ATM and DNA-dependent protein kinase (DNA-PK) are all involved in responding to DNA damage… (More)
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2005
2005
Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel approach to treatment of experimental… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) by oxidant-mediated DNA damage is an important pathway of… (More)
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