Pleiotropic Gene

Known as: Gene, Pleiotropic, Genes, Pleiotropic, Pleiotropic Genes 
A single gene that influences several distinct and seemly unrelated phenotypic outcomes.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
0519722017

Papers overview

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Review
2015
Review
2015
INTRODUCTION Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. Gene variants directly… (More)
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2012
2012
Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively… (More)
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2012
2012
Neph3 (filtrin) is a membrane protein expressed in the glomerular epithelial cells (podocytes), but its role in the glomerulus is… (More)
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2011
2011
Current Genome-Wide Association Studies (GWAS) are performed in a single trait framework without considering genetic correlations… (More)
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2011
2011
Aromatase (CYP19) and estrogen receptor-alpha (ESR1) are involved in the metabolism of estrogens, which have a relevant role in… (More)
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2011
2011
The risk of type 2 diabetes (T2D) increases with obesity. One possible explanation is that pleiotropic genes affect risk of both… (More)
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Highly Cited
2007
Highly Cited
2007
Light is vital for plant growth and development. To respond to ambient light signals, plants are equipped with an array of… (More)
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2003
2003
The effects of arachidonic (AA) and oleic acids (OA) on proliferation, cytokine production and pleiotropic genes expression in… (More)
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2003
2003
Risk factors for coronary heart disease (CHD), including prethrombotic changes in hemostasis, cluster with the insulin resistance… (More)
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1984
1984
A model of selection is described in which optimizing phenotypic selection is combined with pleiotropic overdominance. Thus, the… (More)
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