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Platelet-Activating Factor Acetylhydrolase IB Subunit Beta
Known as:
PAF Acetylhydrolase 30 kDa Subunit
, PAFAH1B2
, PAF-AH Subunit Beta
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Platelet-activating factor acetylhydrolase IB subunit beta (229 aa, ~26 kDa) is encoded by the human PAFAH1B2 gene. This protein is involved in the…
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National Institutes of Health
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Related topics
Related topics
8 relations
Cytoplasm
Enzyme Gene
Esterase Gene
Hydrolase
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.
O. K. Gardner
,
Lily Wang
,
+14 authors
A. Griswold
Human Molecular Genetics
2019
Corpus ID: 174808930
Little is known about the post-transcriptional mechanisms that modulate the genetic effects in the molecular pathways underlying…
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2018
2018
PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer.
C. Ma
,
Yan Guo
,
+4 authors
Binghui Li
Biochemical and Biophysical Research…
2018
Corpus ID: 29156233
2015
2015
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
Rebecca A. Kohnz
,
Melinda M. Mulvihill
,
+6 authors
D. Nomura
ACS Chemical Biology
2015
Corpus ID: 24601513
Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how…
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2012
2012
Loss of PAFAH1B2 Reduces Amyloid-β Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments
R. Page
,
A. Münch
,
+7 authors
C. Haass
Journal of Neuroscience
2012
Corpus ID: 15157007
Amyloid-β peptide (Aβ) is believed to play a central role in the pathogenesis of Alzheimer's disease. In view of the side effects…
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2012
2012
Developmental dynamics of PAFAH1B subunits during mouse brain development
T. Escámez
,
O. Bahamonde
,
R. Tabarés-Seisdedos
,
E. Vieta
,
S. Martínez
,
D. Echevarrı́a
The Journal of comparative neurology
2012
Corpus ID: 23985633
Platelet‐activating factor (PAF) mediates an array of biological processes in the mammalian central nervous system as a bioactive…
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2011
2011
Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood*
Gang Zhou
,
G. Marathe
,
B. Willard
,
T. McIntyre
Journal of Biological Chemistry
2011
Corpus ID: 28067817
Background: Aspirin circulates transiently in blood, but the identity of the enzyme(s) that hydrolyzes its acetyl residue remains…
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2008
2008
Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs.
B. T. Scott
,
N. Olson
,
G. Long
,
E. Bovill
Prostaglandins & other lipid mediators
2008
Corpus ID: 41741787
2007
2007
Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample.
S. Hasstedt
,
B. T. Scott
,
+4 authors
E. Bovill
Thrombosis and Haemostasis
2007
Corpus ID: 7180897
Protein C deficiency increases the risk of venous thromboembolic disease among members of Kindred Vermont II, but fails to fully…
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Highly Cited
2003
Highly Cited
2003
Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis
Wei Yan
,
A. Assadi
,
A. Wynshaw-Boris
,
G. Eichele
,
M. Matzuk
,
G. Clark
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 10762284
Platelet-activating factor (PAF) has been shown to affect sperm motility and acrosomal function, thereby altering fertility. PAF…
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1998
1998
The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.
F. Moro
,
G. Arrigo
,
A. Fogli
,
L. Bernard
,
R. Carrozzo
Genomics
1998
Corpus ID: 20706391
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