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Platelet-Activating Factor Acetylhydrolase IB Subunit Beta

Known as: PAF Acetylhydrolase 30 kDa Subunit, PAFAH1B2, PAF-AH Subunit Beta 
Platelet-activating factor acetylhydrolase IB subunit beta (229 aa, ~26 kDa) is encoded by the human PAFAH1B2 gene. This protein is involved in the… 
National Institutes of Health

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8 relations
CytoplasmEnzyme GeneEsterase GeneHydrolase
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Papers overview

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2019
2019
RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.
Little is known about the post-transcriptional mechanisms that modulate the genetic effects in the molecular pathways underlying… 
2018
2018
PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer.
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B2) plays important roles in inflammation and anaphylaxis… 
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2015
2015
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how… 
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2012
2012
Loss of PAFAH1B2 Reduces Amyloid-β Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments
Amyloid-β peptide (Aβ) is believed to play a central role in the pathogenesis of Alzheimer's disease. In view of the side effects… 
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2012
2012
Developmental dynamics of PAFAH1B subunits during mouse brain development
Platelet‐activating factor (PAF) mediates an array of biological processes in the mammalian central nervous system as a bioactive… 
2011
2011
Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood*
Background: Aspirin circulates transiently in blood, but the identity of the enzyme(s) that hydrolyzes its acetyl residue remains… 
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2008
2008
Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs.
Platelet activating factor acetylhydrolase (paf-ah), a potent regulator of platelet activating factor activity, plays an… 
2007
2007
Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample.
Protein C deficiency increases the risk of venous thromboembolic disease among members of Kindred Vermont II, but fails to fully… 
Highly Cited
2003
Highly Cited
2003
Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis
Platelet-activating factor (PAF) has been shown to affect sperm motility and acrosomal function, thereby altering fertility. PAF… 
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1998
1998
The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.
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