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Platelet-Activating Factor Acetylhydrolase IB Subunit Beta

Known as: PAF Acetylhydrolase 30 kDa Subunit, PAFAH1B2, PAF-AH Subunit Beta 
Platelet-activating factor acetylhydrolase IB subunit beta (229 aa, ~26 kDa) is encoded by the human PAFAH1B2 gene. This protein is involved in the… 
National Institutes of Health

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CytoplasmEnzyme GeneEsterase GeneHydrolase

Papers overview

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2019
2019
RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.
Little is known about the post-transcriptional mechanisms that modulate the genetic effects in the molecular pathways underlying… 
2018
2018
PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer.
2015
2015
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how… 
2012
2012
Loss of PAFAH1B2 Reduces Amyloid-β Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments
Amyloid-β peptide (Aβ) is believed to play a central role in the pathogenesis of Alzheimer's disease. In view of the side effects… 
2012
2012
Developmental dynamics of PAFAH1B subunits during mouse brain development
Platelet‐activating factor (PAF) mediates an array of biological processes in the mammalian central nervous system as a bioactive… 
2011
2011
Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood*
Background: Aspirin circulates transiently in blood, but the identity of the enzyme(s) that hydrolyzes its acetyl residue remains… 
2008
2008
Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs.
2007
2007
Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample.
Protein C deficiency increases the risk of venous thromboembolic disease among members of Kindred Vermont II, but fails to fully… 
Highly Cited
2003
Highly Cited
2003
Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis
Platelet-activating factor (PAF) has been shown to affect sperm motility and acrosomal function, thereby altering fertility. PAF… 
1998
1998
The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively.
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