Pimecrolimus

Known as: 33-Epi-chloro-33-desoxyascomycin, Pimecrolimusum, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- 
A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Genetic defects leading to skin barrier dysfunction were recognized as risk factors for atopic dermatitis (AD). It is… (More)
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Highly Cited
2009
Highly Cited
2009
Psoriasis is a common, chronic, inflammatory, multi-system disease with predominantly skin and joint manifestations affecting… (More)
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Review
2007
Review
2007
BACKGROUND Pimecrolimus was developed as an alternative to topical corticosteroids for treating eczema (atopic dermatitis) but… (More)
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2005
2005
OBJECTIVE To compare the efficacy and safety of tacrolimus ointment and pimecrolimus cream in adult and pediatric patients with… (More)
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Review
2004
Review
2004
Pimecrolimus is the most recent member of calcineurin inhibitors available for the therapy for inflammatory skin diseases. It… (More)
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Highly Cited
2004
Highly Cited
2004
For treatment of skin diseases with topical drugs, penetration of the agents into the relevant layers of the skin is required… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE Pimecrolimus cream (SDZ ASM 981), a nonsteroid inhibitor of inflammatory cytokines, is effective in atopic dermatitis… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The ascomycin derivative pimecrolimus (ASM 981) is a cell-selective cytokine inhibitor, specifically developed for the… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Pimecrolimus cream 1% (Elidel, SDZ ASM 981), a nonsteroid selective inhibitor of inflammatory cytokines, is effective… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Pimecrolimus cream (Elidel, SDZ ASM 981), a non-steroid inhibitor of inflammatory cytokines, is effective in the… (More)
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