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Pimecrolimus

Known as: 33-Epi-chloro-33-desoxyascomycin, Pimecrolimusum, 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- 
A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal… Expand
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Review
2010
Review
2010
Background  The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD must consider the… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Genetic defects leading to skin barrier dysfunction were recognized as risk factors for atopic dermatitis (AD). It is… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
OBJECTIVE During the last decades, management of intertriginous psoriasis (IP) has been unsatisfactory because of the adverse… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE The safety and efficacy of a 1% cream formulation of pimecrolimus, a selective, nonsteroid immunomodulator, was studied… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The ascomycin derivative pimecrolimus (ASM 981) is a cell-selective cytokine inhibitor, specifically developed for the… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE Pimecrolimus cream (SDZ ASM 981), a nonsteroid inhibitor of inflammatory cytokines, is effective in atopic dermatitis… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Pimecrolimus cream 1% (Elidel, SDZ ASM 981), a nonsteroid selective inhibitor of inflammatory cytokines, is effective… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Background: Pimecrolimus is a cell-selective inhibitor of inflammatory cytokine release developed specifically for the treatment… Expand
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Highly Cited
2002
Highly Cited
2002
Background: Pimecrolimus cream (Elidel®, SDZ ASM 981), a non-steroid inhibitor of inflammatory cytokines, is effective in the… Expand
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