Physostigmine

Known as: Physostigmine [Chemical/Ingredient], Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)- 
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1938-2017
05010015019382016

Papers overview

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Highly Cited
2004
Highly Cited
2004
The neurotransmitter acetylcholine is considered essential for proper functioning of the hippocampus-dependent declarative memory… (More)
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Highly Cited
2000
Highly Cited
2000
Using functional magnetic resonance imaging, we investigated the mechanism by which cholinergic enhancement improves working… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND It is postulated that alteration of central cholinergic transmission plays an important role in the mechanism by which… (More)
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1998
1998
BACKGROUND Postanesthetic shivering develops in as many as one half of patients recovering from isoflurane anesthesia… (More)
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Highly Cited
1995
Highly Cited
1995
To investigate further the cholinergic specificity of the effects of basal forebrain lesion-induced disruption of attentional… (More)
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Highly Cited
1992
Highly Cited
1992
Degeneration of the cholinergic magnocellular neurons in the basal forebrain and their cortical projections is a major feature of… (More)
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Highly Cited
1986
Highly Cited
1986
The visual recognition of rhesus monkeys was evaluated by means of a delayed nonmatching-to-sample task with trial-unique objects… (More)
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1985
1985
Twelve patients with Alzheimer's disease received 0.0, 0.5, 1.0, 1.5, and 2.0 mg of oral physostigmine every 2 hours for 3-5 days… (More)
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Highly Cited
1978
Highly Cited
1978
Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion… (More)
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Highly Cited
1977
Highly Cited
1977
Seventy volunteers were injected with diazepam (0.3 mg/kg), scopolamine (8 μg/kg), or placebo, followed 70 min later by another… (More)
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