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Phosphotyrosine Binding Domain

Known as: PTB, PID, PTB Domain 
Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins… 
National Institutes of Health

Related topics

Related topics

11 relations
Amyloid Beta A4 Precursor Protein-Binding Family A Member 1Amyloid Beta A4 Precursor Protein-Binding Family A Member 2Amyloid Beta A4 Precursor Protein-Binding Family A Member 3DOK1 protein, human

Papers overview

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Highly Cited
2004
Highly Cited
2004
Nucleolin Is a Second Component of the CD154 mRNA Stability Complex That Regulates mRNA Turnover in Activated T Cells1
CD154 (CD40L) mRNA turnover is regulated in part at the posttranscriptional level by a protein complex (termed Complex I) that… 
Highly Cited
2000
Highly Cited
2000
Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB
A monoclonal antibody raised against nuclear matrix proteins detected a protein of basic pI in human nuclear matrix protein… 
Highly Cited
1999
Highly Cited
1999
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB.
In this study, we demonstrate the ability of the polypyrimidine tract binding protein PTB to function as a coordinator of… 
Highly Cited
1999
Highly Cited
1999
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding
  • Gregg Siegal
  • Nature Structural Biology
  • 1999
  • Corpus ID: 52849786
Although ligand-induced receptor dimerization is a common prerequisite for receptor activation, the mode by which different… 
Highly Cited
1997
Highly Cited
1997
Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus
The synthesis of picornavirus polyproteins is initiated cap independently far downstream from the 5' end of the viral RNA at the… 
Highly Cited
1996
Highly Cited
1996
Binding Affinities of Tyrosine-phosphorylated Peptides to the COOH-terminal SH2 and NH-terminal Phosphotyrosine Binding Domains of Shc (*)
The adaptor protein Shc has been implicated in Ras signaling via association with many tyrosine-phosphorylated receptors… 
Review
1996
Review
1996
The PI/PTB domain: a new protein interaction domain involved in growth factor receptor signaling.
Highly Cited
1996
Highly Cited
1996
Interaction between the Phosphotyrosine Binding Domain of Shc and the Insulin Receptor Is Required for Shc Phosphorylation by Insulin in Vivo(*)
Stimulation of the insulin receptor (IR) results in tyrosine phosphorylation of the intermediate molecules insulin receptor… 
1996
1996
Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction (*)
Shc is an Src homology 2 (SH2) domain protein thought to be an important component of the signaling pathway leading from cell… 
Highly Cited
1975
Highly Cited
1975
Pentobarbital and contraction of vascular smooth muscle.
This study, with isolated rat aortic strips and portal veins, was undertaken to : 1) study the effects, if any, of pentobarbital… 
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