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Phosphotyrosine Binding Domain

Known as: PTB, PID, PTB Domain 
Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins… Expand
National Institutes of Health

Related topics

Related topics

11 relations
Amyloid Beta A4 Precursor Protein-Binding Family A Member 1Amyloid Beta A4 Precursor Protein-Binding Family A Member 2Amyloid Beta A4 Precursor Protein-Binding Family A Member 3DOK1 protein, human
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Papers overview

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Highly Cited
2018
Highly Cited
2018
A New Method
 
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Highly Cited
2013
Highly Cited
2013
Performance of the LHCb RICH detector at the LHC
The LHCb experiment has been taking data at the Large Hadron Collider (LHC) at CERN since the end of 2009. One of its key… Expand
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Highly Cited
2013
Highly Cited
2013
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Answers from Exomes Exome sequencing, which targets only the protein-coding regions of the genome, has the potential to identify… Expand
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Highly Cited
2010
Highly Cited
2010
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB
To gain global insights into the role of the well-known repressive splicing regulator PTB, we analyzed the consequences of PTB… Expand
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Review
2010
Review
2010
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It… Expand
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Highly Cited
2005
Highly Cited
2005
Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger… Expand
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Highly Cited
2003
Highly Cited
2003
Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling
The cytoplasmic domains (tails) of heterodimeric integrin adhesion receptors mediate integrins' biological functions by binding… Expand
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Highly Cited
2003
Highly Cited
2003
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs
Scansite identifies short protein sequence motifs that are recognized by modular signaling domains, phosphorylated by protein Ser… Expand
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Highly Cited
1997
Highly Cited
1997
The discoidin domain receptor tyrosine kinases are activated by collagen.
Two mammalian receptor tyrosine kinases (DDR1 and DDR2) have extracellular domains closely related to a D. discoideum lectin… Expand
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Highly Cited
1995
Highly Cited
1995
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of She complexed to a phosphopeptide reveals… Expand
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