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The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine salvage pathway, and PNP deficiency in… Expand We had previously shown that high gene expressions (mRNA levels) of thymidylate synthase (TS; Leichman et al., J. Clin. Oncol… Expand Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive human disease associated with multiple… Expand Glycogen phosphorylase plays a central role in the mobilization of carbohydrate reserves in a wide variety of organisms and… Expand Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three… Expand The inhibitory effect of a marine-sponge toxin, okadaic acid, was examined on type 1, type 2A, type 2B and type 2C protein… Expand Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-src and pp110gag-fes was inhibited… Expand A 5-year-old girl with a history of recurrent infection and anaemia has no measurable purine nucleoside phosphorylase (N.P… Expand The suggestion of Lipmann' that the energy required to drive this reaction to the right came from adenosine triphosphate has been… Expand The concentration of phosphorylase in liver slices changes rapidly in response to certain experimental conditions (14). The… Expand