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Phospholipase C delta

Known as: Phosphoinositide Specific Phospholipase C delta, Phosphoinositide-Specific Phospholipase C delta, Phospholipase C delta [Chemical/Ingredient] 
A phosphoinositide phospholipase C subtype that is structurally defined by the presence of an N-terminal pleckstrin-homology and EF-hand domains, a… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodPLCD3 genePLCD4 geneProcess of secretion

Narrower (6)

PLCD1 protein, humanPLCD3 protein, humanPhospholipase C delta1Phospholipase C delta4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy… 
Highly Cited
2007
Highly Cited
2007
Depolarization activates the phosphoinositide phosphatase Ci‐VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2
Voltage‐evoked signals play critical roles in neural activities, muscle contraction and exocytosis. Ciona voltage‐sensor… 
Highly Cited
2002
Highly Cited
2002
Inositol Lipid Binding and Membrane Localization of Isolated Pleckstrin Homology (PH) Domains
The relationship between the ability of isolated pleckstrin homology (PH) domains to bind inositol lipids or soluble inositol… 
Highly Cited
2002
Highly Cited
2002
Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray
Highly Cited
1998
Highly Cited
1998
Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2*
Cytosolic phospholipase A2 (cPLA2) is a calcium-sensitive 85-kDa enzyme that hydrolyzes arachidonic acid-containing membrane… 
Highly Cited
1998
Highly Cited
1998
Group IV Cytosolic Phospholipase A2 Binds with High Affinity and Specificity to Phosphatidylinositol 4,5-Bisphosphate Resulting in Dramatic Increases in Activity*
The group IV cytosolic phospholipase A2 (cPLA2) exhibits a potent and specific increase in affinity for lipid surfaces containing… 
Highly Cited
1996
Highly Cited
1996
A New Phospholipase C 4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus (*)
To discover a new phospholipase C (PLC) related to cell growth, we screened a cDNA library prepared from regenerating rat liver… 
Highly Cited
1995
Highly Cited
1995
Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane.
The structural requirements of phospholipase C delta 1 for interaction with the plasma membrane were analysed by… 
Highly Cited
1995
Highly Cited
1995
Cloning and Identification of Amino Acid Residues of Human Phospholipase Cδ1 Essential for Catalysis (*)
In vitro single point mutagenesis, inositol phospholipid hydrolysis, and substrate protection experiments were used to identify… 
Highly Cited
1992
Highly Cited
1992
Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.
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