Phosphatidylinositol Glycan

Based on the oncogenic role of phosphatidylinositol glycan (PIG) class U in human tumors, we explored the role of two additional… Expand

Secreted proteins are processed from a nascent form that contains an NHz-terminal signal peptide. During processing, the latter… Expand

Diagnostic enzymology measures the serum or plasma levels of enzymes that were originally located within the cell, or were… Expand

Fc gamma RIIA (CD32), a conventional type I transmembrane protein, and Fc gamma RIIIB (CD16B), which has a glycan… Expand

Patients with paroxysmal nocturnal haemoglobinuria (PNH) have in their blood two red-cell populations, one normal and one… Expand

Paroxysmal nocturnal haemoglobinuria (PNH) is due to the absence or marked reduction of glycan phosphatidylinositol (GPI… Expand

The PIG-A gene, whose product is involved in one of the early steps in the synthesis of glycan phosphatidylinositol (GPI) anchors… Expand

Enzymes bound to the surfaces of cells may be retained by a hydrophobic amino acid sequence (e.g. gamma-glutamyltransferase) or… Expand

Granulocyte and natural killer (NK) cell Fc receptors for immunoglobulin G (CD16) differ in only a few amino acids, yet have… Expand

Fc receptors on phagocytic cells in the blood mediate binding and clearance of immune complexes, phagocytosis of antibody… Expand