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Phosphatidylinositide 3-Kinase Inhibitor

Known as: PI3-Kinase Inhibitors, Phosphatidylinositol 3-kinase Inhibitor 
Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
BACKGROUND To evaluate the safety, tolerability, pharmacokinetics, and maximum tolerated dose (MTD) of copanlisib, a… Expand
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Highly Cited
2008
Highly Cited
2008
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2-positive breast cancer who have progressed on… Expand
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Highly Cited
2007
Highly Cited
2007
Angiotensin-(1-7) [Ang-(1-7)] causes endothelial-dependent vasodilation mediated, in part, by NO release. However, the molecular… Expand
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Highly Cited
2004
Highly Cited
2004
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated… Expand
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Highly Cited
2003
Highly Cited
2003
Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin. However, mechanisms by which adiponectin… Expand
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Highly Cited
2002
Highly Cited
2002
Recent evidence shows the involvement of reactive oxygen species (ROS) in the mitogenic cascade initiated by the tyrosine kinase… Expand
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Highly Cited
2001
Highly Cited
2001
Oncogenic transformation and hypoxia both induceglut1 mRNA. We studied the interaction between theras oncogene and hypoxia in up… Expand
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Highly Cited
1998
Highly Cited
1998
The nuclear factor CREB stimulates the expression of cellular genes following its protein kinase A-mediated phosphorylation at… Expand
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Highly Cited
1996
Highly Cited
1996
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after… Expand
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Highly Cited
1993
Highly Cited
1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… Expand
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