Phosphatidylinositide 3-Kinase Inhibitor

Known as: PI3-Kinase Inhibitors, Phosphatidylinositol 3-kinase Inhibitor 
Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
0204019932017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Small molecule inhibitors of HER2 are clinically active in women with advanced HER2-positive breast cancer who have progressed on… (More)
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Highly Cited
2006
Highly Cited
2006
Polarity is a central feature of eukaryotic cells and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) has a central… (More)
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Highly Cited
2004
Highly Cited
2004
Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated… (More)
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Highly Cited
2003
Highly Cited
2003
Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin. However, mechanisms by which adiponectin… (More)
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Highly Cited
2001
Highly Cited
2001
Oncogenic transformation and hypoxia both induce glut1 mRNA. We studied the interaction between the ras oncogene and hypoxia in… (More)
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Highly Cited
1999
Highly Cited
1999
Chemokines play a central role for lymphocyte trafficking and homing. The mechanisms that direct the tissue localization of B… (More)
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Highly Cited
1999
Highly Cited
1999
Aims/hypothesis. Glucagon-like peptide-1 is a potent glucoincretin hormone and a potentially important drug in the treatment of… (More)
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Highly Cited
1998
Highly Cited
1998
The nuclear factor CREB stimulates the expression of cellular genes following its protein kinase A-mediated phosphorylation at… (More)
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Highly Cited
1996
Highly Cited
1996
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after… (More)
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Highly Cited
1993
Highly Cited
1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… (More)
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