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Phorbol 12,13-Dibutyrate

Known as: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-, Phorbol 12,13 Dibutyrate, Phorbol 12,13-Dibutyrate [Chemical/Ingredient] 
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated… 
National Institutes of Health

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6 relations

Broader (2)

CarcinogensPhorbol Esters
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
1993
Highly Cited
1993
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
Highly Cited
1990
Highly Cited
1990
Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.
Highly Cited
1990
Highly Cited
1990
Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C.
Highly Cited
1989
Highly Cited
1989
1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils.
Highly Cited
1988
Highly Cited
1988
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
Highly Cited
1985
Highly Cited
1985
Induction of protein kinase C activation and Ca2+ mobilization by fibroblast growth factor in Swiss 3T3 cells
Highly Cited
1985
Highly Cited
1985
Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium
: We have found that maximum stimulation (greater than 10-fold) of kinase activity of a bovine brain preparation of calcium- and… 
Highly Cited
1984
Highly Cited
1984
Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.
Highly Cited
1984
Highly Cited
1984
Inhibition of denuded mouse oocyte meiotic maturation by tumor-promoting phorbol esters and its reversal by retinoids.
Highly Cited
1975
Highly Cited
1975
Surface properties of phorbol esters and their interaction with lipid monolayers and bilayers.
The potent tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) is surface active and was found to occupy a limiting… 
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