Phorbol 12,13-Dibutyrate

Known as: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-, Phorbol 12,13 Dibutyrate, Phorbol 12,13-Dibutyrate [Chemical/Ingredient] 
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
05010019752018

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Highly Cited
2004
Highly Cited
2004
TRPV4 is a Ca(2+)- and Mg(2+)-permeable cation channel within the vanilloid receptor subgroup of the transient receptor potential… (More)
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Highly Cited
2001
Highly Cited
2001
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the… (More)
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Highly Cited
1998
Highly Cited
1998
The effects of the Rho-kinase inhibitor, Y-27632 [1] on Ca2+-sensitization of force induced by arachidonic acid (AA), phorbol 12… (More)
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1996
1996
BACKGROUND Activation of either protein kinase C or the ATP-sensitive potassium channel has been shown to induce the… (More)
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Highly Cited
1991
Highly Cited
1991
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… (More)
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Highly Cited
1989
Highly Cited
1989
Protein kinase C normally has a tandem repeat of a characteristic cysteine-rich sequence in C1, the conserved region of the… (More)
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1989
1989
The mechanism(s) of force development in vascular smooth muscle following pharmacological activation of protein kinase C by… (More)
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Highly Cited
1988
Highly Cited
1988
Mechanisms responsible for broad-based resistance to antitumor drugs derived from natural products (multidrug resistance) are… (More)
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1987
1987
Phorbol dibutyrate (PDB) is an activator of protein kinase C and has been observed to cause a slow developing contraction in… (More)
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1980
1980
[20-3H]Phorbol 12,13-dibutyrate ([3H]PDBU) and [20-3H]-phorbol 12-myristate 13-acetate ([3H]PMA) bound specifically and with high… (More)
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