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Phorbol 12,13-Dibutyrate

Known as: Butanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa(3,4)benz(1,2-e)azulene-9,9a-diyl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-, Phorbol 12,13 Dibutyrate, Phorbol 12,13-Dibutyrate [Chemical/Ingredient] 
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating… Expand
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Highly Cited
2008
Highly Cited
2008
Activation of the non-selective cation channel TRPV4 by mechanical and osmotic stimuli requires the involvement of phospholipase… Expand
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Highly Cited
2007
Highly Cited
2007
Cell-cell communication in astroglial syncytia is mediated by intracellular Ca(2+) ([Ca(2+)](i)) responses elicited by… Expand
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Highly Cited
2006
Highly Cited
2006
The synthesis and study of a new redox family of symmetric dinuclear iron(II/III) complexes featuring "(eta(2)-dppe)(eta(5)-C(5… Expand
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Highly Cited
2003
Highly Cited
2003
Polyyn-diyls capped by Ru(2)(ap)(4) termini (ap = 2-anilinopyridinate), that is, [Ru2(ap)4](mu-C,C'-C2m)[Ru2(ap)4] (compounds 1-5… Expand
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Highly Cited
2002
Highly Cited
2002
Recent evidence supports a beneficial effect of testosterone on the cardiovascular system. Testosterone acts as a coronary… Expand
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Highly Cited
2001
Highly Cited
2001
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the… Expand
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Highly Cited
1991
Highly Cited
1991
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand
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Highly Cited
1989
Highly Cited
1989
Protein kinase C normally has a tandem repeat of a characteristic cysteine-rich sequence in C1, the conserved region of the… Expand
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Highly Cited
1987
Highly Cited
1987
Lysosphingolipids potently and reversibly inhibited protein kinase C activity and binding of phorbol dibutyrate in vitro and in… Expand
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