Pharmacological Chaperone

Known as: Pharmaceutical Chaperone 
Any agent that helps restore the function of the endogenous mutated protein. Pharmaceutical chaperones may help stabilize the protein structure… (More)

Topic mentions per year

Topic mentions per year

2008-2016
02420082016

Papers overview

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2017
2017
BACKGROUND Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal… (More)
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2016
2016
Aspartylglucosaminuria (AGU) is a lysosomal storage disorder that is caused by genetic deficiency of the enzyme… (More)
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2016
2016
A unique molecular library consisting of all sixteen synthetic ADMDP (1-aminodeoxy-DMDP) stereoisomers has been prepared and… (More)
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2015
2015
Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the gene that encodes α-galactosidase A and is… (More)
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2015
2015
Alcoholic liver disease (ALD) is characterized by the development of steatosis, inflammation, hepatocyte necrosis, and apoptosis… (More)
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2015
2015
Pyranoid-type glycomimetics having a cis-1,2-fused glucopyranose-2-alkylsulfanyl-1,3-oxazoline (Glc-PSO) structure exhibit an… (More)
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2012
2012
Fabry disease is an X-linked lysosomal storage disorder (LSD) caused by mutations in the gene (GLA) that encodes the lysosomal… (More)
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2009
2009
In spite of the progress in the treatment of lysosomal storage diseases (LSDs), in some of these disorders the available… (More)
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Review
2009
Review
2009
The acronym SePhaChARNS, for “selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry,” is… (More)
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2008
2008
INTRODUCTION Pharmacological chaperone therapy (PCT) is a developing area in the treatment of diseases characterized by misfolded… (More)
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