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Peptide Nucleic Acid Clamping

Known as: Peptide Nucleic Acid Clamp, PCR Clamp, Peptide Nucleic Acid-mediated Competitive-PCR Clamping 
A modification of the standard polymerase chain reaction that increases the ability to preferentially amplify mutant alleles in the presence of an… Expand
National Institutes of Health

Papers overview

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2010
2010
Objective:To identify colon cancer patients with occult lymph node metastases. Summary of Background Data:The prognostic value of… Expand
2008
2008
Sensitive detection of tumor-specific point mutations is of interest in both the early detection of cancer and the monitoring of… Expand
Highly Cited
2007
Highly Cited
2007
Purpose: Somatic B-RAF gene mutation has been identified in many malignancies and detected at a high frequency in cutaneous… Expand
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2007
2007
The detection of rare mutant DNA from a background of wild-type alleles usually requires laborious manipulations, such as… Expand
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Highly Cited
2006
Highly Cited
2006
The major problem of using somatic mutations as markers of malignancy is that the clinical samples are frequently containing a… Expand
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2006
2006
Background and aimsSince the introduction of endovascular aortic aneurysm repair (EVAR) for aortic aneurysms, the number of… Expand
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2004
2004
Emergence of lamivudine‐resistant variants, with amino acid substitutions in the Tyr‐Met‐Asp‐Asp (YMDD) motif of hepatitis B… Expand
Highly Cited
2000
Highly Cited
2000
ABSTRACT Peptide nucleic acid (PNA)-mediated PCR clamping (H. Ørum, P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt, and C… Expand
Highly Cited
1999
Highly Cited
1999
Although much is known about the mechanisms of signal-mediated protein and RNA nuclear import and export, little is understood… Expand
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Highly Cited
1998
Highly Cited
1998
Hereditary hemochromatosis (HH), an iron overload disease, is the most common known inheritable disease. The most prevalent form… Expand
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