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Peptide Nucleic Acid Clamping

Known as: Peptide Nucleic Acid Clamp, PCR Clamp, Peptide Nucleic Acid-mediated Competitive-PCR Clamping 
A modification of the standard polymerase chain reaction that increases the ability to preferentially amplify mutant alleles in the presence of an… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND: KRAS status is a useful predictive marker for anti-epidermal growth factor receptor antibody therapy. OBJECTIVE: This… Expand
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2010
2010
Objective:To identify colon cancer patients with occult lymph node metastases. Summary of Background Data:The prognostic value of… Expand
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2008
2008
Sensitive detection of tumor-specific point mutations is of interest in both the early detection of cancer and the monitoring of… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: Somatic B-RAF gene mutation has been identified in many malignancies and detected at a high frequency in cutaneous… Expand
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Highly Cited
2006
Highly Cited
2006
The major problem of using somatic mutations as markers of malignancy is that the clinical samples are frequently containing a… Expand
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2006
2006
Background and aimsSince the introduction of endovascular aortic aneurysm repair (EVAR) for aortic aneurysms, the number of… Expand
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2004
2004
Emergence of lamivudine‐resistant variants, with amino acid substitutions in the Tyr‐Met‐Asp‐Asp (YMDD) motif of hepatitis B… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT Peptide nucleic acid (PNA)-mediated PCR clamping (H. Ørum, P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt, and C… Expand
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Highly Cited
1999
Highly Cited
1999
Although much is known about the mechanisms of signal-mediated protein and RNA nuclear import and export, little is understood… Expand
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Highly Cited
1998
Highly Cited
1998
Hereditary hemochromatosis (HH), an iron overload disease, is the most common known inheritable disease. The most prevalent form… Expand
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