Peptide Nucleic Acid Clamping

Known as: Peptide Nucleic Acid Clamp, PCR Clamp, Peptide Nucleic Acid-mediated Competitive-PCR Clamping 
A modification of the standard polymerase chain reaction that increases the ability to preferentially amplify mutant alleles in the presence of an… (More)
National Institutes of Health

Papers overview

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2012
2012
BACKGROUND Papillary thyroid carcinoma (PTC) of the thyroid is the most common endocrine malignancy. High prevalence of an… (More)
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2012
2012
We investigated the effectiveness of peptide nucleic acid (PNA) clamp PCR for detecting KRAS mutations in peripheral blood… (More)
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2010
2010
OBJECTIVE To identify colon cancer patients with occult lymph node metastases. SUMMARY OF BACKGROUND DATA The prognostic value… (More)
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2008
2008
Sensitive detection of tumor-specific point mutations is of interest in both the early detection of cancer and the monitoring of… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Somatic B-RAF gene mutation has been identified in many malignancies and detected at a high frequency in cutaneous… (More)
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2006
2006
The major problem of using somatic mutations as markers of malignancy is that the clinical samples are frequently containing a… (More)
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2006
2006
The detection of rare mutant DNA from a background of wild-type alleles usually requires laborious manipulations, such as… (More)
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2003
2003
The emergence of drug-resistant mutants of hepatitis B virus (HBV) is a serious problem during antiviral therapy of patients with… (More)
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2000
2000
Peptide nucleic acid (PNA)-mediated PCR clamping (H. Orum, P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt, and C. Stanley… (More)
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1998
1998
Hereditary hemochromatosis (HH), an iron overload disease, is the most common known inheritable disease. The most prevalent form… (More)
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