Peptide/MHC Complex

Known as: Peptide-MHC, Peptide-Major Histocompatibility Protein Complex, pMHC 
Peptide MHC Complexes consist of proteolytically-processed low molecular weight amino acid fragments of antigenic foreign proteins noncovalently… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
020406019822017

Papers overview

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Highly Cited
2010
Highly Cited
2010
The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T… (More)
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Highly Cited
2006
Highly Cited
2006
Major histocompatibility complex (MHC) class I molecules present peptide ligands on the cell surface for recognition by… (More)
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Highly Cited
2005
Highly Cited
2005
T cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen… (More)
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Highly Cited
2005
Highly Cited
2005
The binding of a T-cell antigen receptor (TCR) to peptide antigen presented by major histocompatibility antigens (pMHC) on… (More)
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Highly Cited
2005
Highly Cited
2005
The energetic bases of T cell recognition are unclear. Here, we studied the 'energetic landscape' of peptide–major… (More)
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Highly Cited
2002
Highly Cited
2002
To initiate an immune response, key receptor-ligand pairs must cluster in “immune synapses” at the T cell–antigen-presenting cell… (More)
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Highly Cited
1999
Highly Cited
1999
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign peptide antigen, and the I-Ak self… (More)
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Highly Cited
1998
Highly Cited
1998
The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation… (More)
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Highly Cited
1996
Highly Cited
1996
The central event in the cellular immune response to invading microorganisms is the specific recognition of foreign peptides… (More)
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Highly Cited
1991
Highly Cited
1991
The interaction of antigen-specific T cell receptors (TCRs) with their ligands, peptides bound to molecules of the major… (More)
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