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Penicillopepsin
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (1)
Aspartic Acid Endopeptidases
aspergillopepsin I
cytosol nonspecific dipeptidase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.
A. R. Khan
,
J. C. Parrish
,
M. Fraser
,
W. Smith
,
P. Bartlett
,
M. James
Biochemistry
1998
Corpus ID: 19939688
The design of inhibitors with enhanced potency against proteolytic enzymes has many applications for the treatment of human…
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Highly Cited
1994
Highly Cited
1994
Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.
J. Jiang
,
A. Brünger
Journal of molecular biology
1994
Corpus ID: 7978225
Solvation in macromolecular crystal structures was studied by analyzing X-ray diffraction data of two proteins, penicillopepsin…
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Highly Cited
1993
Highly Cited
1993
Assessment of Phase Accuracy by Cross Validation: the Free R Value. Methods and Applications
A. T. Brunger
1993
Corpus ID: 53474048
Analogies between the free R statistic [Brunger (1992). Nature (London), 355, 472–474] and the statistical methods of cross…
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Highly Cited
1993
Highly Cited
1993
Assessment of phase accuracy by cross validation: the free R value. Methods and applications.
A. Brünger
Acta crystallographica. Section D, Biological…
1993
Corpus ID: 2454481
Analogies between the free R statistic [Brünger (1992). Nature (London), 355, 472-474] and the statistical methods of cross…
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1992
1992
Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues.
M. Fraser
,
N. Strynadka
,
P. Bartlett
,
J. E. Hanson
,
M. James
Biochemistry
1992
Corpus ID: 34345520
The molecular structures of three phosphorus-based peptide inhibitors of aspartyl proteinases complexed with penicillopepsin [1…
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Highly Cited
1985
Highly Cited
1985
Stereochemical analysis of peptide bond hydrolysis catalyzed by the aspartic proteinase penicillopepsin.
M. James
,
A. Sielecki
Biochemistry
1985
Corpus ID: 9617005
The X-ray crystal structures of native penicillopepsin and of its complex with a synthetic analogue of the inhibitor pepstatin…
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Highly Cited
1983
Highly Cited
1983
Structure and refinement of penicillopepsin at 1.8 A resolution.
M. James
,
A. Sielecki
Journal of molecular biology
1983
Corpus ID: 35074027
Abstract Penicillopepsin, the aspartyl protease from the mould Penicillium janthinellum , has had its molecular structure refined…
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Highly Cited
1982
Highly Cited
1982
Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.
M. James
,
A. Sielecki
,
F. Salituro
,
D. Rich
,
T. Hofmann
Proceedings of the National Academy of Sciences…
1982
Corpus ID: 23105865
Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase…
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Highly Cited
1977
Highly Cited
1977
Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin
I-Nan Hsu
,
L. Delbaere
,
M. James
,
T. Hofmann
Nature
1977
Corpus ID: 4196351
The polypeptide chain of the acid protease penicillopepsin folds via an 18-stranded mixed β-sheet into two distinct lobes…
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Highly Cited
1977
Highly Cited
1977
Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin
M. James
,
I-Nan Hsu
,
L. Delbaere
Nature
1977
Corpus ID: 4211135
A proposed mechanism for the catalytic hydrolysis of peptide bonds by acid proteases is similar in many respects to the Zn…
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