Pegylated Recombinant Human Hyaluronidase PH20

Known as: PEGPH20, Pegylated Recombinant Human PH20, Pegylated rHuPH20 
A pegylated formulation of a recombinant form of human hyaluronidase with potential antitumor activity. Upon intravenous administration, pegylated… (More)
National Institutes of Health

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2010-2018
02420102018

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2016
2016
PURPOSE This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in… (More)
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2016
2016
Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly… (More)
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2015
2015
Many biological activities have been reported for hyaluronan (HA, an extracellular matrix glycosaminoglycan), including… (More)
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2014
2014
Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and… (More)
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Highly Cited
2013
Highly Cited
2013
OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which… (More)
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2013
2013
Increased deposition of specific extracellular matrix (ECM) components is a characteristic of insulin-resistant skeletal muscle… (More)
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2013
2013
Over the last twenty years, there is a limited number of effective cytotoxic or biological agents that managed to get approval in… (More)
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2012
2012
BACKGROUND The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan… (More)
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2012
2012
Pancreatic ductal adenocarcinoma (PDA) responds poorly to chemotherapy. In this issue of Cancer Cell, Provenzano et al. identify… (More)
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2010
2010
Hyaluronan (HA) is a glycosaminoglycan polymer that often accumulates in malignancy. Megadalton complexes of HA with… (More)
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