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Pazopanib Hydrochloride

Known as: 5-((4-((2,3-Dimethyl-2h-Indazol-6-Yl)Methylamino)Pyrimidin-2-yl)Amino)-2-Methylbenzenesulfonamide Monohydrochloride 
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib… Expand
National Institutes of Health

Papers overview

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2018
2018
Purpose: PROTECT, a phase III, randomized, placebo-controlled study, evaluated pazopanib efficacy and safety in the adjuvant… Expand
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2017
2017
Studies focused on the killing of activated B-RAF melanoma cells by the histone deacetylase (HDAC) inhibitor AR42. Compared to… Expand
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2017
2017
BackgroundPazopanib is an angiogenesis inhibitor approved for the treatment of renal cell carcinoma and soft tissue sarcoma. Post… Expand
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2016
2016
Purpose: Pazopanib is a tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma and soft tissue sarcoma… Expand
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2015
2015
BACKGROUND Patients treated with the standard dose of pazopanib show a large interpatient variability in drug exposure defined as… Expand
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2014
2014
BackgroundRecently, the phase III PALETTE study introduced pazopanib (Votrient®) as treatment for adult patients with locally… Expand
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2014
2014
Abstract Background: The metabolism of tyrosine kinase inhibitors (TKIs) is mainly mediated via hepatic route, but the mechanism… Expand
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Highly Cited
2013
Highly Cited
2013
PurposeThe metabolism of pazopanib is primarily mediated by CYP3A4. The solubility of pazopanib is pH-dependent, and an elevated… Expand
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2009
2009
OBJECTIVE To investigate pazopanib hydrochloride, a multitargeted kinase inhibitor, for treatment of choroidal neovascularization… Expand
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2009
2009
Pharmaceutical regulatory agencies are increasingly concerned with trace-level genotoxic impurities in drug substances, requiring… Expand
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