Parkinson Disease 6, Autosomal Recessive Early-Onset

Known as: Parkinson Disease 6, Early-Onset, PARKINSON DISEASE, AUTOSOMAL RECESSIVE EARLY-ONSET, DIGENIC, PINK1/DJ1, PARK6 
 
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
The PARKIN ubiquitin ligase (also known as PARK2) and its regulatory kinase PINK1 (also known as PARK6), often mutated in… (More)
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Review
2012
Review
2012
Several forms of autosomal recessive parkinsonism are known. In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6… (More)
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Highly Cited
2007
Highly Cited
2007
In mice, targeted deletion of the serine protease HtrA2 (also known as Omi) causes mitochondrial dysfunction leading to a… (More)
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Highly Cited
2007
Highly Cited
2007
Degeneration of dopaminergic neurons in the substantia nigra is characteristic for Parkinson's disease (PD), the second most… (More)
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Review
2007
Review
2007
The association of six genes with monogenic forms of parkinsonism has unambiguously established that the disease has a genetic… (More)
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Highly Cited
2004
Highly Cited
2004
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia… (More)
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Highly Cited
2004
Highly Cited
2004
We have recently reported homozygous mutations in the PINK1 gene in three consanguineous families with early-onset parkinsonism… (More)
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Highly Cited
2003
Highly Cited
2003
Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known… (More)
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2001
2001
Although the role of genetic factors in the origin of Parkinson disease has long been disputed, several genes involved in… (More)
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2001
2001
The cause of Parkinson disease (PD) is still unknown, but genetic factors have recently been implicated in the etiology of the… (More)
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