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Paraparesis, Spastic

Known as: Spastic paraparesis, Lower Extremity Weakness, Spastic, Spastic Parapareses 
Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS… 
National Institutes of Health

Related topics

Related topics

18 relations
CCDC88C geneCyproheptadineCyproheptadine hydrochlorideGaucher Disease, Type 3 (disorder)

Narrower (1)

Gemignani syndrome

Papers overview

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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease with spastic paraparesis and 'cotton wool' plaques: two pedigrees with PS-1 exon 9 deletions.
Several pedigrees have recently been reported in which dominantly inherited familial Alzheimer's disease is associated in some… 
Highly Cited
2000
Highly Cited
2000
HTLV-I specific IFN-γ+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals
Highly Cited
2000
Highly Cited
2000
Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p
Objectives: To investigate whether cognitive decline is part of the phenotype of SPG4-linked hereditary spastic paraparesis (HSP… 
Highly Cited
1998
Highly Cited
1998
Autosomal dominant hereditary spastic paraparesis with cognitive loss linked to chromosome 2p.
A family initially considered to have 'pure' autosomal dominant hereditary spastic paraparesis (HSP), was found on… 
Review
1993
Review
1993
HTLV-1 Tax: regulation of gene expression and disease.
Highly Cited
1993
Highly Cited
1993
Spastic ataxia associated with human T‐cell lymphotrophic virus type II infection
Human T‐cell lymphotropic virus type one (HTLV‐1) is associated with tropical spastic paraparesis or HTLV‐I‐associated myelopathy… 
Highly Cited
1992
Highly Cited
1992
A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in…
Human T lymphocyte virus type I (HTLV-I) can be transmitted into several inbred strains of newborn and adult rats by inoculating… 
Highly Cited
1991
Highly Cited
1991
Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients.
Highly Cited
1990
Highly Cited
1990
Excessive muscular fatigue in patients with spastic paraparesis
We used intermittent tetanic contractions and 31P magnetic resonance spectroscopy to investigate human tibialis anterior muscle… 
Highly Cited
1977
Highly Cited
1977
Paraparesis following intrathecal cytosine arabinoside. A case report with neuropathologic findings
A 65‐year‐old white male with acute myelogenous leukemia received whole brain irradiation (2550 rads) and intrathecal cytosine… 
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