Papillomavirus Transforming Protein E6

Known as: E6, Viral Protein E6 
Binds to and promotes degradation of p53 protein resulting in disruption of cell cycle regulation.
National Institutes of Health

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Review
2009
Review
2009
The papillomaviruses are small DNA viruses that encode approximately eight genes, and require the host cell DNA replication… (More)
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Highly Cited
2003
Highly Cited
2003
The targeted inhibition of antiapoptotic factors in tumour cells may provide a rational approach towards the development of novel… (More)
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Highly Cited
2000
Highly Cited
2000
The high-risk human papillomavirus (HPV) E6 proteins stimulate the ubiquitination and degradation of p53, dependent on the E6AP… (More)
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Highly Cited
1999
Highly Cited
1999
The co-activators CBP and p300 are important for normal cell differentiation and cell cycle progression and are the targets for… (More)
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Highly Cited
1998
Highly Cited
1998
Interferon regulatory factor-3 (IRF-3) was found to specifically interact with HPV16 E6 in a yeast two-hybrid screen. IRF-3 is… (More)
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Highly Cited
1997
Highly Cited
1997
In the majority of cervical cancers, DNAs of high-risk mucosotpropic human papillomaviruses (HPVs), such as type 16, are… (More)
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Highly Cited
1996
Highly Cited
1996
ACTIVATION of telomerase, a ribonucleoprotein complex that synthesizes telomere repeat sequences1–4, is linked to cell… (More)
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Highly Cited
1993
Highly Cited
1993
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins… (More)
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Highly Cited
1990
Highly Cited
1990
The E6 protein encoded by the oncogenic human papillomavirus types 16 and 18 is one of two viral products expressed in HPV… (More)
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Highly Cited
1990
Highly Cited
1990
Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two… (More)
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