Pan-IDH Mutant Inhibitor AG-881

Known as: Pan IDH Mutant Inhibitor AG-881, AG-881, AG881 
An orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2… (More)
National Institutes of Health

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2018
2018
Some mutations of isocitrate dehydrogenase 1 and 2 observed in multiple kinds of malignant tumors can lead to a neomorphic enzyme… (More)
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Review
2016
Review
2016
Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Recurrent… (More)
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Highly Cited
2014
Highly Cited
2014
PURPOSE Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology… (More)
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2011
2011
Mutations in the gene encoding isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have recently been identified in a… (More)
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2008
2008
Mitochondrial NAD(+)-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative… (More)
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1995
1995
A 0.6 kb cDNA fragment encoding the human NAD(+)-specific isocitrate dehydrogenase alpha-subunit (H-IDH alpha) was amplified by… (More)
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1993
1993
Bigraphs are graphs whose nodes may be nested, representing locality, independently of the edges connecting them. T hey may be… (More)
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1989
1989
A dynamic communication network is one in which links may repeatedly fail and recover. In such a network, though it is impossible… (More)
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