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Pan-IDH Mutant Inhibitor AG-881

Known as: Pan IDH Mutant Inhibitor AG-881, AG-881, AG881 
An orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2… Expand
National Institutes of Health

Papers overview

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2018
2018
  • Rui Ma, C. Yun
  • Biochemical and biophysical research…
  • 2018
  • Corpus ID: 52055771
Some mutations of isocitrate dehydrogenase 1 and 2 observed in multiple kinds of malignant tumors can lead to a neomorphic enzyme… Expand
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2018
2018
2002Background: Isocitrate dehydrogenase 1 and 2 mutations (mIDH1/2) occur in solid tumors including glioma, and result in… Expand
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2018
2018
AG-881 is an orally available, brain penetrant, potent, small-molecule inhibitor of isocitrate dehydrogenase (IDH) 1 and IDH2… Expand
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Review
2016
Review
2016
Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. Recurrent… Expand
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Highly Cited
2014
Highly Cited
2014
PURPOSE Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations in the gene encoding isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have recently been identified in a… Expand
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2010
2010
OBJETIVO: Analisar a associacao entre indicadores sociais e ambientais e o coeficiente de deteccao de hanseniase (CDH) na… Expand
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2008
2008
Mitochondrial NAD+-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative… Expand
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1995
1995
A 0.6 kb cDNA fragment encoding the human NAD(+)-specific isocitrate dehydrogenase alpha-subunit (H-IDH alpha) was amplified by… Expand
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1993
1993
Bigraphs are graphs whose nodes may be nested, representing locality, independently of the edges connecting them. T hey may be… Expand
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