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PTTG1 protein, human

Known as: hPTTG protein, TUTR1 protein, human, securin, human 
Securin (202 aa, ~22 kDa) is encoded by the human PTTG1 gene. This protein plays a role in chromosomal maintenance.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Deregulation of the pituitary tumor transforming gene (PTTG1), a newly discovered oncogene, is a hallmark of various malignancies… Expand
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Highly Cited
2013
Highly Cited
2013
As the most abundant liver-specific microRNA, miR-122 is involved in diverse aspects of hepatic function and neoplastic… Expand
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Highly Cited
2013
Highly Cited
2013
Deeper mechanistic understanding of non-small cell lung cancer (NSCLC), a leading cause of total cancer-related deaths, may… Expand
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2013
2013
BACKGROUND Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC… Expand
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Highly Cited
2006
Highly Cited
2006
The pituitary tumor transforming (PTTG) gene family comprises PTTG1, 2, and 3. Forced expression of PTTG1 (securin) induces… Expand
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2005
2005
Human Securin, also called PTTG1 (pituitary tumor transforming gene 1 product), is an estrogen-regulated proto-oncogene with… Expand
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Highly Cited
2004
Highly Cited
2004
BackgroundPituitary tumor transforming gene1 (PTTG1) is a novel oncogene that is expressed in most tumors. It encodes a protein… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister… Expand
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Highly Cited
2001
Highly Cited
2001
Separation of sister chromatids in anaphase is mediated by separase, an endopeptidase that cleaves the chromosomal cohesin SCC1… Expand
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Highly Cited
2001
Highly Cited
2001
Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of… Expand
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