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PTPRC protein, human
Known as:
protein tyrosine phosphatase, receptor type C protein, human
, CD45
, T200 Glycoprotein
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Receptor-type tyrosine-protein phosphatase C (1304 aa, ~147 kDa) is encoded by the human PTPRC gene. This protein plays a role in protein…
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National Institutes of Health
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Related topics
Related topics
15 relations
Broader (1)
CD45 Antigens
Dephosphorylation
Enzyme Gene
Esterase Gene
Hydrolase
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Altered CD45 expression and disease.
E. Tchilian
,
P. Beverley
Trends in immunology
2006
Corpus ID: 32247733
Highly Cited
2003
Highly Cited
2003
Differential Regulation of CXCR4-mediated T-cell Chemotaxis and Mitogen-activated Protein Kinase Activation by the Membrane Tyrosine Phosphatase, CD45*
A. Fernandis
,
Rama P. Cherla
,
R. Ganju
Journal of Biological Chemistry
2003
Corpus ID: 38628023
The chemokine receptor CXCR4 and its cognate ligand, stromal cell-derived factor-1α (CXCL12), regulate lymphocyte trafficking and…
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Highly Cited
2000
Highly Cited
2000
A point mutation in PTPRC is associated with the development of multiple sclerosis
M. Jacobsen
,
D. Schweer
,
+13 authors
B. Hemmer
Nature Genetics
2000
Corpus ID: 2171883
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. It is widely accepted that a…
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Highly Cited
1990
Highly Cited
1990
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
G. Koretzky
,
J. Picus
,
M. Thomas
,
A. Weiss
Nature
1990
Corpus ID: 4229035
STIMULATION of T lymphocytes through their antigen receptor (T-cell receptor; TCR) results in the activation of a tyrosine…
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Highly Cited
1989
Highly Cited
1989
A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.
M. Streuli
,
N. X. Krueger
,
A. Tsai
,
H. Saito
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 20788461
To understand the regulation of cell proliferation by tyrosine phosphorylation, characterization of protein tyrosine phosphatases…
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Highly Cited
1988
Highly Cited
1988
Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.
H. Serra
,
J. Krowka
,
Ledbetter Ja
,
L. Pilarski
Journal of Immunology
1988
Corpus ID: 20022738
CD45R+ and CDw29+ CD4+ T cells are widely regarded as separate functionally defined T cell lineages. The work described here…
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Highly Cited
1988
Highly Cited
1988
CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.
Jeffrey A. Ledbetter
,
N. Tonks
,
Edmond H. Fischer
,
Edward A. Clark
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 22897436
Evidence is presented that the leukocyte common antigen CD45 can regulate both signal transduction by lymphocyte receptor…
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Highly Cited
1985
Highly Cited
1985
Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies
L. Lefrançois
,
M. Bevan
Nature
1985
Corpus ID: 20157191
Plasma membrane glycoproteins of cytotoxic T lymphocytes (CTLs) are involved in the binding to and subsequent destruction of…
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Highly Cited
1980
Highly Cited
1980
Human homologue of murine T200 glycoprotein
M. B. Omary
,
I. S. Trowbridge
,
H A Battifora
Journal of Experimental Medicine
1980
Corpus ID: 7802043
We report the identification of the human homologue of murine T200 glycoprotein. Peptide-mapping experiments suggest that the…
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Highly Cited
1978
Highly Cited
1978
Interspecies spleen-myeloma hybrid producing monoclonal antibodies against mouse lymphocyte surface glycoprotein, T200
B. I. S. Trowbridge
Journal of Experimental Medicine
1978
Corpus ID: 13580488
A cell hybrid has been selected from fusion of a mouse myeloma and rat spleen cells immunized against mouse lymphoma cells that…
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