PTPN22 protein, human

Known as: PTPN8 protein, human, PTPN22, LyP 
Tyrosine-protein phosphatase non-receptor type 22 (807 aa, ~92 kDa) is encoded by the human PTPN22 gene. This protein is involved in both protein… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
A variant of the PTPN22-encoded Lyp phosphatase (Lyp620W) confers risk for autoimmune disease, but the mechanisms underlying this… (More)
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Highly Cited
2011
Highly Cited
2011
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The… (More)
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Review
2007
Review
2007
The discovery that a single-nucleotide polymorphism (SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is… (More)
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Review
2006
Review
2006
The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with a number of different autoimmune… (More)
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Highly Cited
2006
Highly Cited
2006
Stimulation of mature T cells activates a downstream signaling cascade involving temporally and spatially regulated… (More)
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Highly Cited
2005
Highly Cited
2005
Autoimmune disorders constitute a diverse group of phenotypes with overlapping features and a tendency toward familial… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE Analyses of families with multiple autoimmune disorders have revealed a functional polymorphism, 620W, in the… (More)
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Highly Cited
2005
Highly Cited
2005
The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein… (More)
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Highly Cited
2004
Highly Cited
2004
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W… (More)
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Highly Cited
1999
Highly Cited
1999
Protein tyrosine phosphatases act in conjunction with protein kinases to regulate the tyrosine phosphorylation events that… (More)
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