PTPN11 protein, human

Known as: SHP-2, PTPN11, SHP2 Phosphatase 
Tyrosine-protein phosphatase non-receptor type 11 (597 aa, ~68 kDa) is encoded by the human PTPN11 gene. This protein is involved in hormone-mediated… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
LEOPARD syndrome (LS) is an autosomal dominant "RASopathy" that manifests with congenital heart disease. Nearly all cases of LS… (More)
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2009
2009
Several protein phosphatases are involved in neuroprotection in response to ischemic brain injury. Here, we report that reactive… (More)
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Review
2008
Review
2008
Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and… (More)
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Review
2007
Review
2007
Tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs… (More)
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Highly Cited
2004
Highly Cited
2004
The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for normal development and is an essential… (More)
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Highly Cited
2004
Highly Cited
2004
Noonan syndrome is a developmental disorder with dysmorphic facies, short stature, cardiac defects, and skeletal anomalies, which… (More)
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Highly Cited
2004
Highly Cited
2004
Epidermal growth factor (EGF) induces paxillin tyrosine dephosphorylation and Src activation, but the signaling pathways that… (More)
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Highly Cited
2002
Highly Cited
2002
Fluid shear stress (FSS) induces many forms of responses, including phosphorylation of extracellular signal-regulated kinase (ERK… (More)
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Highly Cited
1999
Highly Cited
1999
Flt3 ligand (FL) is an early-acting potent co-stimulatory cytokine that regulates proliferation and differentiation of a number… (More)
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Highly Cited
1993
Highly Cited
1993
Much progress has been made in elucidating early events in signal transduction by growth factor receptors with intrinsic tyrosine… (More)
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