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PTK787/ZK 222584

Known as: PTK787/ZK-222584, PTK787/ZK222584 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
FTY720, a potent immunomodulator, becomes phosphorylated in vivo (FTY-P) and interacts with sphingosine-1-phosphate (S1P… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE PTK787/ZK 222584 (PTK/ZK) is an oral angiogenesis inhibitor targeting all known vascular endothelial growth factor (VEGF… Expand
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Highly Cited
2005
Highly Cited
2005
LBA3 Background: PTK787/ZK 222584 (PTK/ZK) is a novel, oral, small molecule, anti-angiogenesis compound that blocks tyrosine… Expand
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Highly Cited
2004
Highly Cited
2004
1513 Background: VEGF-mediated signaling through VEGF receptors is integral to GBM neovascularization and therefore an attractive… Expand
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Review
2003
Review
2003
It is widely accepted that tumour growth beyond a few cubic millimetres cannot occur without the induction of a new vascular… Expand
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Highly Cited
2002
Highly Cited
2002
Striking homology between signaling molecules in zebrafish and humans suggests that compounds known to inhibit human kinases may… Expand
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Review
2001
Review
2001
Protein kinases play a crucial role in signal transduction as well as in cellular proliferation, differentiation, and various… Expand
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Highly Cited
2000
Highly Cited
2000
PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate) is a potent inhibitor of vascular endothelial… Expand
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Highly Cited
2000
Highly Cited
2000
Antiangiogenic therapy is a promising new strategy to inhibit tumor growth and formation of metastases. Vascular endothelial… Expand
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Highly Cited
2000
Highly Cited
2000
Malignant pleural effusion (PE) is associated with advanced human lung cancer. We found recently, using a nude mouse model, that… Expand
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