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PTK6 gene

Known as: BRK, PROTEIN-TYROSINE KINASE 6, PROTEIN-TYROSINE KINASE BRK 
This gene plays a role in signal transduction.
National Institutes of Health

Related topics

Related topics

11 relations
Breast CarcinomaCell Differentiation processCell ProliferationHomo sapiens

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PTK6 wt Allele

Papers overview

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2015
2015
Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase* ♦
Background: The view that, unlike kinases, phosphatases are “nonspecific” pervades the field. Results: PTP1B inhibited BRK by… 
2013
2013
PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.
2013
2013
Effects of Simultaneous Knockdown of HER2 and PTK6 on Malignancy and Tumor Progression in Human Breast Cancer Cells
Breast cancer is the most common malignancy in women of the Western world. One prominent feature of breast cancer is the co- and… 
Highly Cited
2011
Highly Cited
2011
Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell
Cisplatin resistance is one of the major reasons leading to the high death rate of ovarian cancer. Methyl-Capture sequencing… 
2011
2011
Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.
PTK6, also known as Brk, is highly expressed in over 80% of breast cancers. In the last decade several substrates and interaction… 
2010
2010
Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells*
STAP-2 (signal transducing adaptor protein-2) is a recently identified adaptor protein that contains pleckstrin homology (PH) and… 
2007
2007
Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6.
1991
1991
Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells.
The expression of the junB gene parallels the expression of the MHC class I genes in Adenovirus (Ad) transformed cells. In Ad12E1… 
1989
1989
Localization, cloning, and expression of genetic determinants for bacteriophage resistance (Hsp) from the conjugative plasmid pTR2030
Genetic determinants for a bacteriophage resistance mechanism (Hsp+) encoded by plasmid pTR2030 (46.2 kilobases [kb]) were… 
Highly Cited
1986
Highly Cited
1986
Lytic and transforming functions of individual products of the adenovirus E1A gene
To distinguish the individual roles of the 13S, 12S, and 9S adenovirus E1A gene products, we isolated the corresponding cDNA… 
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