PTEN protein, human

Known as: Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN, phosphatase and tensin homolog protein, human, MMAC1 protein, human 
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2018
050019642018

Papers overview

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Highly Cited
2008
Highly Cited
2008
MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing… (More)
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Highly Cited
2006
Highly Cited
2006
Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in… (More)
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Highly Cited
2005
Highly Cited
2005
Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro… (More)
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Highly Cited
2005
Highly Cited
2005
Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit… (More)
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Highly Cited
2002
Highly Cited
2002
The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the 3'-phosphate of phosphoinositides… (More)
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Highly Cited
2001
Highly Cited
2001
Recent evidence places the FRAP/mTOR kinase downstream of the phosphatidyl inositol 3-kinase/Akt-signaling pathway, which is up… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… (More)
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Highly Cited
1998
Highly Cited
1998
PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN… (More)
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Highly Cited
1997
Highly Cited
1997
Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN… (More)
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