PTEN protein, human

Known as: Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN, phosphatase and tensin homolog protein, human, MMAC1 protein, human 
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN… (More)
National Institutes of Health

Related topics

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18 relations
CTCF PathwayDUSP10 protein, humanDephosphorylationEnzyme Gene
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Broader (1)

PTEN Phosphohydrolase

Papers overview

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Highly Cited
2013
Highly Cited
2013
A pseudogene long noncoding RNA network regulates PTEN transcription and translation in human cells
PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding… (More)
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Highly Cited
2011
Highly Cited
2011
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.
We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common… (More)
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Highly Cited
2007
Highly Cited
2007
Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression
The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility… (More)
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Highly Cited
2001
Highly Cited
2001
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.
The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by dephosphorylating phosphatidylinositol… (More)
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Highly Cited
2000
Highly Cited
2000
Loss of PTEN facilitates HIF-1-mediated gene expression.
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or cause complete inhibition of DNA… (More)
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Highly Cited
1999
Highly Cited
1999
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
PTEN/MMAC1 is a tumor suppressor gene located on chromosome 10q23. Inherited PTEN/MMAC1 mutations are associated with a cancer… (More)
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Highly Cited
1998
Highly Cited
1998
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… (More)
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Highly Cited
1998
Highly Cited
1998
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their… (More)
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Highly Cited
1998
Highly Cited
1998
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
The PTEN/MMAC1 phosphatase is a tumor suppressor gene implicated in a wide range of human cancers. Here we provide biochemical… (More)
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Highly Cited
1998
Highly Cited
1998
Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways
The tumor suppressor PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits integrin-mediated cell spreading and cell… (More)
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