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PSMB5 gene

Known as: PSX LARGE MULTIFUNCTIONAL PROTEASE X, LMPX, Proteasome (Prosome, Macropain) Subunit, Beta Type, 5 Gene 
This gene plays a role in proteasome-mediated proteolysis.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Engineering and study of protein function by directed evolution has been limited by the technical requirement to use global… Expand
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Highly Cited
2013
Highly Cited
2013
Eukaryotes have two major intracellular protein degradation pathways, namely the ubiquitin-proteasome system (UPS) and autophagy… Expand
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Highly Cited
2012
Highly Cited
2012
Bortezomib (BTZ), a registered proteasome inhibitor (PI) for multiple myeloma, has also been proposed as a potential… Expand
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Highly Cited
2010
Highly Cited
2010
Bortezomib is an effective agent for treating multiple myeloma (MM). To investigate the underlying mechanisms associated with… Expand
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2010
2010
The expression of a variety of cytoprotective genes is regulated by short cis-acting elements in their promoters, called… Expand
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2009
2009
OBJECTIVE To investigate the relationship between bortezomib resistance and mutations in the proteasome beta5 subunit (PSMB5… Expand
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Highly Cited
2008
Highly Cited
2008
The proteasome inhibitor bortezomib is a novel anticancer drug that has shown promise in the treatment of refractory multiple… Expand
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2008
2008
OBJECTIVE To study the mechanism of bortezomib resistance in JurkatB lines derived from T-lymphoblastic lymphoma/leukemia Jurkat… Expand
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2006
2006
The 26S proteasome is responsible for degradation of abnormal intracellular proteins, including oxidatively damaged proteins and… Expand
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Highly Cited
2003
Highly Cited
2003
Proteasomes degrade damaged proteins formed during oxidative stress, thereby promoting cell survival. Neurodegenerative and other… Expand
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