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PSMA-targeted Tubulysin B-containing Conjugate EC1169

Known as: EC1169, EC1719 
An injectable, water soluble, small molecule drug conjugate (SMDC) containing a ligand specific for prostate-specific membrane antigen (PSMA… Expand
National Institutes of Health

Papers overview

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2019
2019
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the… Expand
2018
2018
The targeted delivery of chemotherapeutic agents to receptors that are overexpressed on cancer cells has become an attractive… Expand
2018
2018
  • E. Waltz
  • Nature Biotechnology
  • 2018
  • Corpus ID: 54448159
particles. But instead of yttrium-90, Lutathera uses lutetium-177, a lower energy isotope that avoids some of the collateral… Expand
2015
2015
ABSTRACT Background: EC1169 is a conjugate of a prostate-specific membrane antigen (PSMA) targeting moiety linked to tubulysin B… Expand
2015
2015
2586Background: EC1169 is a small molecule drug conjugate designed to bind to prostate cancer (PCa) cells via prostate specific… Expand
2013
2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Prostate-specific membrane antigen (PSMA) is a… Expand
Highly Cited
2009
Highly Cited
2009
The first total synthesis of tubulysin B is described. The aziridine route to tubuphenylalanine (Tup) of the tubulysin D/U-series… Expand