PSMA-targeted Tubulysin B-containing Conjugate EC1169
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Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the… Expand The targeted delivery of chemotherapeutic agents to receptors that are overexpressed on cancer cells has become an attractive… Expand particles. But instead of yttrium-90, Lutathera uses lutetium-177, a lower energy isotope that avoids some of the collateral… Expand ABSTRACT Background: EC1169 is a conjugate of a prostate-specific membrane antigen (PSMA) targeting moiety linked to tubulysin B… Expand 2586Background: EC1169 is a small molecule drug conjugate designed to bind to prostate cancer (PCa) cells via prostate specific… Expand Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC
Prostate-specific membrane antigen (PSMA) is a… Expand The first total synthesis of tubulysin B is described. The aziridine route to tubuphenylalanine (Tup) of the tubulysin D/U-series… Expand