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PSENEN wt Allele

Known as: Presenilin Enhancer 2 Homolog (C. elegans) wt Allele, PEN-2, PEN2 
Human PSENEN wild-type allele is located in the vicinity of 19q13.12 and is approximately 1 kb in length. This allele, which encodes gamma-secretase… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Background Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman… Expand
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Highly Cited
2010
Highly Cited
2010
A defence pathway contributing to non-host resistance to biotrophic fungi in Arabidopsis involves the synthesis and targeted… Expand
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Highly Cited
2009
Highly Cited
2009
Selection pressure exerted by insects and microorganisms shapes the diversity of plant secondary metabolites. We identified a… Expand
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Highly Cited
2009
Highly Cited
2009
The perception of pathogen or microbe-associated molecular pattern molecules by plants triggers a basal defense response… Expand
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease is associated with increased production and aggregation of amyloid-beta (Abeta) peptides. Abeta peptides are… Expand
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Highly Cited
2003
Highly Cited
2003
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… Expand
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Highly Cited
2003
Highly Cited
2003
Alzheimer's disease is associated with increased production and aggregation of amyloid-β (Aβ) peptides. Aβ peptides are derived… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract γ-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Aβ. A… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… Expand
  • figure 1
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  • figure 4
  • figure 5
Is this relevant?