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PSENEN wt Allele

Known as: Presenilin Enhancer 2 Homolog (C. elegans) wt Allele, PEN-2, PEN2 
Human PSENEN wild-type allele is located in the vicinity of 19q13.12 and is approximately 1 kb in length. This allele, which encodes gamma-secretase… 
National Institutes of Health

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Alzheimer's Disease Pathway KEGGApoptosisNotch Signaling PathwayRegulation of Proteolysis

Papers overview

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2016
2016
SOBIR1 contributes to non-host resistance to Magnaporthe oryzae in Arabidopsis
The rate of entry of Magnaporthe oryzae into Arabidopsis pen2 sobir1 plants was significantly higher than that into pen2 plants… 
2009
2009
Conformational analysis of enkephalin analogs containing a disulfide bond. Models for delta- and mu-receptor opioid agonists.
Conformational analysis of the cyclic opioids H-Tyr-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) and H-Tyr-D-Cys-Gly-Phe-D-Cys-OH (DCDCE) have… 
Review
2008
Review
2008
From presenilinase to gamma-secretase, cleave to capacitate.
Mutations in two genes, presenilin 1 (PS1) and its homologue presenilin 2 (PS2), account for a majority of early onset familial… 
2006
2006
N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53.
2006
2006
Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB
ABSTRACT Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's β-amyloid precursor protein (APP… 
2005
2005
Aph‐1 interacts at the cell surface with proteins in the active γ‐secretase complex and membrane‐tethered Notch
The activity of the γ‐secretase complex is critical for the processing of a number of transmembrane proteins, including Notch… 
2004
2004
Co-expression of Nicastrin and Presenilin Rescues a Loss of Function Mutant of APH-1*
γ-Secretase is an intramembrane-cleaving aspartyl protease complex that mediates the final cleavage of β-amyloid precursor… 
2004
2004
PEN‐2 enhances γ‐cleavage after presenilin heterodimer formation
The presenilin (PS) complex, including PS, nicastrin, APH‐1 and PEN‐2, is essential for γ‐secretase activity, which is required… 
2004
2004
Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation*
Familial Alzheimer's disease mutations in the presenilin 1 gene (PSEN1) have been previously shown to potentiate caspase… 
2003
2003
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
Gamma-secretase cleavage is the final enzymatic step generating beta-amyloid via intramembranous cleavage of the amyloid… 
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