PSENEN wt Allele

Known as: Presenilin Enhancer 2 Homolog (C. elegans) wt Allele, PEN-2, PEN2 
Human PSENEN wild-type allele is located in the vicinity of 19q13.12 and is approximately 1 kb in length. This allele, which encodes gamma-secretase… (More)
National Institutes of Health

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1989-2017
0102019892017

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2010
2010
A defence pathway contributing to non-host resistance to biotrophic fungi in Arabidopsis involves the synthesis and targeted… (More)
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2005
Highly Cited
2005
Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet… (More)
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2004
Highly Cited
2004
Mitochondria are central in the regulation of cell death. Apart from providing the cell with ATP, mitochondria also harbor… (More)
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2004
2004
Gamma-secretase is a member of an unusual class of proteases with intramembrane catalytic sites. This enzyme cleaves many type I… (More)
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2003
Highly Cited
2003
gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated… (More)
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2003
Highly Cited
2003
gamma-Secretase catalyzes the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of… (More)
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Highly Cited
2003
Highly Cited
2003
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… (More)
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2003
Highly Cited
2003
Presenilin (PS, PS1/PS2) complexes are known to be responsible for the intramembranous gamma-secretase cleavage of the beta… (More)
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2002
Highly Cited
2002
Presenilins are components of the gamma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch… (More)
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2002
Highly Cited
2002
The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active site of gamma-secretase, an unusual… (More)
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