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PSENEN gene

Known as: PRESENILIN ENHANCER 2, C. ELEGANS, HOMOLOG OF, PSENEN, PEN2 
This gene plays a role in the regulation of both gamma-secretase activity and Notch signaling pathways.
National Institutes of Health

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ApoptosisGamma-Secretase Subunit PEN-2PSEN1 geneRegulation of Proteolysis

Papers overview

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2020
2020
Scrotal Dowling–Degos disease caused by a novel frameshift variant in gamma‐secretase subunit presenile enhancer gene
We reported a Chinese pedigree with scrotal Dowling–Degos disease and evaluated the phenotypic and genotypic characteristics. In… 
2018
2018
Comorbidities or different entities? Phenotype variability associated with PSENEN mutations
Acne Inversa (AI), also called hidradenitis suppurativa, is a clinically heterogeneous skin disease featured by painful boils… 
2017
2017
[Effect of βsheet blocking peptide H102 on APP metabolic enzymes in hippocampal brain of double transgenic AD mice].
OBJECTIVE To investigate the effect of β-sheet breaker peptide H102 on APP associated secretase in the hippocampus brain regions… 
2017
2017
Maladie de Dowling-Degos et hidradénite suppurée : 2 nouveaux cas associés à une mutation de PSENEN
2016
2016
A Case Report of Inversa Acne and Evaluation for Mutations in the NCSTN, PSENEN, and PSEN1 Genes
To the Editor: Acne inversa (AI; OMIM: 142690) is a painful chronic follicular disease, characterized by recurrent draining… 
2016
2016
γ-secretase activating protein (GSAP) does not specifically affect the γ-secretase processing of APP
Alzheimer’s disease (AD) is characterized by the cerebral accumulation of β-amyloid (Aβ) peptide, which is generated by… 
2012
2012
Preclinical Development Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells
Cancer stem cells are implicated in resistance to ionizing radiation (IR) and chemotherapy. Honokiol, a biphenolic compound has… 
2005
2005
Presenilin immunoreactivity in Alzheimer's disease
The role of presenilin (PS) mutations in familial Alzheimer's disease (AD) may be as a toxic gain of function, but in sporadic… 
2004
2004
PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample
PEN2 is a reasonable Alzheimer’s disease (AD) candidate gene because it is a necessary component of the γ-secretase complex that… 
1998
1998
Conformational analysis of beta-methyl-para-nitrophenylalanine stereoisomers of cyclo[D-Pen2, D-Pen5]enkephalin by NMR spectroscopy and conformational energy calculations.
Solution conformations of beta-methyl-para-nitrophenylalanine4 analogues of the potent delta-opioid peptide cyclo[D-Pen2, D-Pen5… 
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