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PSEN2 gene

Known as: STM2, Presenilin 2 (Alzheimer Disease 4) Gene, PS2 
This gene is involved in the regulation of proteolysis.
National Institutes of Health

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Alzheimer's DiseaseApoptosisHydrolysisPSEN2 protein, human

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PSEN2 wt Allele

Papers overview

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2007
2007
Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain
BackgroundThe transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the… 
2004
2004
Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production
Background: At least half of all cases of early onset (<60) familial Alzheimer’s disease (FAD) are caused by any of over 150… 
2002
2002
Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.
Although it has been established that oxidative stress mediates cytotoxicity by familial Alzheimer's disease (FAD)-linked mutants… 
2002
2002
Molecular cloning and characterization of CALP / KChIP 4 , a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv 4
2002
2002
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis… 
2000
2000
Mutational Analysis of Intrinsic Regions of Presenilin 2 That Determine Its Endoproteolytic Cleavage and Pathological Function*
To investigate the significance of endoproteolytic processing of presenilin 2 (PS2) on its pathological function, we constructed… 
1998
1998
Epidemiologic and Genetic Studies of Dementia of the Alzheimer Type in Japan
We carried out two separate epidemiological studies on long-term changes, 10 years apart, on the prevalence rate of dementia in… 
1997
1997
Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines.
Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes are associated with early-onset autosomal dominant familial… 
1997
1997
Neuronal Expression and Intracellular Localization of Presenilins in Normal and Alzheimer Disease Brains
The expression patterns of presenilin 1 (PS1) and presenilin 2 (PS2) in human normal and Alzheimer disease (AD) brains were… 
1996
1996
Apolipoprotein E and amyloidogenesis.
Alzheimer's amyloid beta-protein (A beta) is a modified, pathogenic form of a constitutive host protein, soluble amyloid beta… 
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