PSEN2 gene

Known as: STM2, Presenilin 2 (Alzheimer Disease 4) Gene, PS2 
This gene is involved in the regulation of proteolysis.

Topic mentions per year

Topic mentions per year

1982-2017
0204019822017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia… (More)
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Highly Cited
2011
Highly Cited
2011
Alzheimer's disease (AD) is the most common form of age-related dementia, characterized by progressive memory loss and cognitive… (More)
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Highly Cited
2006
Highly Cited
2006
The varied ways in which mutations in presenilins (PSEN1 and PSEN2) affect amyloid b precursor protein (APP) processing in… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in the homologous presenilin 1 (PS1) and presenilin 2 (PS2) genes cause the most common and aggressive form of familial… (More)
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Highly Cited
1998
Highly Cited
1998
Most early-onset familial Alzheimer disease (AD) cases are caused by mutations in the highly related genes presenilin 1 (PS1) and… (More)
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Highly Cited
1997
Highly Cited
1997
Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2), cause dementia in a subset of early… (More)
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Highly Cited
1997
Highly Cited
1997
CONTEXT Four genetic loci have been identified as contributing to Alzheimer disease (AD), including the amyloid precursor protein… (More)
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Highly Cited
1996
Highly Cited
1996
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's… (More)
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to… (More)
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Highly Cited
1996
Highly Cited
1996
Mutations in two recently identified genes appear to cause the majority of early–onset familial Alzheimer's disease (FAD). These… (More)
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