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PSEN1 gene

Known as: PS1, FAD, S182 
This gene plays a role in proteolysis.
National Institutes of Health

Related topics

Related topics

9 relations
Alzheimer's DiseaseHydrolysisPSENEN genePositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA‐133a inhibits gastric cancer cells growth, migration, and epithelial‐mesenchymal transition process by targeting presenilin 1
Gastric cancer (GC) is one of the most common malignancies and a leading cause of cancer‐related death worldwide. Accumulating… 
2009
2009
Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors*
Presenilin 1, a protein involved in the development of familial Alzheimer disease, is an important functional component of the… 
2002
2002
The Mechanism of γ-Secretase Activities through High Molecular Weight Complex Formation of Presenilins Is Conserved inDrosophila melanogaster and Mammals*
Mutations in presenilin 1 (PS1) and PS2 genes contribute to the pathogenesis of early onset familial Alzheimer's disease by… 
Review
2000
Review
2000
In search of γ-secretase: Presenilin at the cutting edge
The effort to solve Alzheimer's disease (AD) has led to a salutary intersection between the desire to prevent a major health… 
2000
2000
Inhibiting Amyloid Precursor Protein C-terminal Cleavage Promotes an Interaction with Presenilin 1*
Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-β protein, which is central to the pathogenesis of… 
Highly Cited
1999
Highly Cited
1999
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
Highly Cited
1998
Highly Cited
1998
Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures
1997
1997
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease
Highly Cited
1996
Highly Cited
1996
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains
Many individuals with familial Alzheimer disease (FAD) have mutations in a gene termed S182 or presenilin I (PS‐I). Currently… 
1996
1996
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains.
Many individuals with familial Alzheimer disease (FAD) have mutations in a gene termed S182 or presenilin I (PS-I). Currently… 
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