PSEN1 gene

Known as: PS1, FAD, S182 
This gene plays a role in proteolysis.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia… (More)
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Review
2010
Review
2010
Three decades of genetic research in Alzheimer disease (AD) have substantially broadened our understanding of the pathogenetic… (More)
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Highly Cited
2004
Highly Cited
2004
The endoplasmic reticulum (ER) provides an environment that is highly optimized for oxidative protein folding. Rather than… (More)
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Highly Cited
1999
Highly Cited
1999
Accumulation of the amyloid-β protein (Aβ) in the cerebral cortex is an early and invariant event in the pathogenesis of… (More)
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Highly Cited
1996
Highly Cited
1996
MUTATIONS in the genes encoding amyloid-β precursor protein (APP)1 presenilin 1 (PS1)2 and presenilin 2 (PS2)3,4 are known to… (More)
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Highly Cited
1996
Highly Cited
1996
To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to… (More)
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Highly Cited
1995
Highly Cited
1995
WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence… (More)
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Highly Cited
1995
Highly Cited
1995
A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for… (More)
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Highly Cited
1995
Highly Cited
1995
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic linkage studies have mapped a locus (AD3… (More)
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Highly Cited
1995
Highly Cited
1995
THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12 / Notch family of receptors for intercellular… (More)
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