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PSEN1 gene
Known as:
PS1
, FAD
, S182
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This gene plays a role in proteolysis.
National Institutes of Health
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Related topics
Related topics
9 relations
Alzheimer's Disease
Hydrolysis
PSENEN gene
Positive Regulation of Apoptosis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA‐133a inhibits gastric cancer cells growth, migration, and epithelial‐mesenchymal transition process by targeting presenilin 1
Xinbing Chen
,
Wei Li
,
Ai-Xia Chu
Journal of Cellular Biochemistry
2018
Corpus ID: 52137508
Gastric cancer (GC) is one of the most common malignancies and a leading cause of cancer‐related death worldwide. Accumulating…
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2009
2009
Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors*
Jindong Xu
,
C. Litterst
,
A. Georgakopoulos
,
I. Zaganas
,
N. Robakis
Journal of Biological Chemistry
2009
Corpus ID: 19906523
Presenilin 1, a protein involved in the development of familial Alzheimer disease, is an important functional component of the…
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2002
2002
The Mechanism of γ-Secretase Activities through High Molecular Weight Complex Formation of Presenilins Is Conserved inDrosophila melanogaster and Mammals*
N. Takasugi
,
Yasuko Takahashi
,
Y. Morohashi
,
T. Tomita
,
T. Iwatsubo
Journal of Biological Chemistry
2002
Corpus ID: 34794215
Mutations in presenilin 1 (PS1) and PS2 genes contribute to the pathogenesis of early onset familial Alzheimer's disease by…
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Review
2000
Review
2000
In search of γ-secretase: Presenilin at the cutting edge
D. Selkoe
,
M. Wolfe
2000
Corpus ID: 32485260
The effort to solve Alzheimer's disease (AD) has led to a salutary intersection between the desire to prevent a major health…
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2000
2000
Inhibiting Amyloid Precursor Protein C-terminal Cleavage Promotes an Interaction with Presenilin 1*
G. Verdile
,
R. Martins
,
Monika Duthie
,
E. Holmes
,
P. S. St George-Hyslop
,
P. Fraser
Journal of Biological Chemistry
2000
Corpus ID: 21564574
Presenilin 1 (PS1) plays a pivotal role in the production of the amyloid-β protein, which is central to the pathogenesis of…
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Highly Cited
1999
Highly Cited
1999
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
O. Berezovska
,
M. Frosch
,
+8 authors
B. Hyman
Brain Research. Molecular Brain Research
1999
Corpus ID: 23604515
Highly Cited
1998
Highly Cited
1998
Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures
C. Czech
,
M. Lesort
,
+10 authors
L. Pradier
Neuroscience
1998
Corpus ID: 27764052
1997
1997
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease
C. Forsell
,
S. Froelich
,
+10 authors
L. Lannfelt
Neuroscience Letters
1997
Corpus ID: 7607197
Highly Cited
1996
Highly Cited
1996
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains
Gregory A. Elder
,
N. Tezapsidis
,
+7 authors
N. Robakis
1996
Corpus ID: 196584029
Many individuals with familial Alzheimer disease (FAD) have mutations in a gene termed S182 or presenilin I (PS‐I). Currently…
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1996
1996
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains.
G. Elder
,
N. Tezapsidis
,
+7 authors
N. Robakis
Journal of Neuroscience Research
1996
Corpus ID: 24418953
Many individuals with familial Alzheimer disease (FAD) have mutations in a gene termed S182 or presenilin I (PS-I). Currently…
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