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PS 341

Known as: 341, PS, PS-341, PS341 
National Institutes of Health

Related topics

Related topics

2 relations
LDP-341

Broader (1)

bortezomib

Papers overview

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Highly Cited
2011
Highly Cited
2011
Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory B-Cell Neoplasms
Purpose: A phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the… 
2008
2008
Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3′-untranslated region
Addition of proteasome inhibitor PS-341 (VELCADE, bortezomib) to prostate cancer cells enhances cell death mediated by tumor… 
Highly Cited
2006
Highly Cited
2006
Immunosensitization of Tumor Cells to Dendritic Cell-Activated Immune Responses with the Proteasome Inhibitor Bortezomib (PS-341, Velcade)1
Proteasome inhibition results in proapoptotic changes in cancer cells, which may make them more sensitive to immune effector… 
2005
2005
Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341
The farnesyl transferase inhibitor R115777 has been found to have clinical activity in diverse hematopoietic tumors. Clinical… 
Review
2005
Review
2005
Novel biological therapies for the treatment of multiple myeloma.
Highly Cited
2004
Highly Cited
2004
Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic… 
Highly Cited
2004
Highly Cited
2004
Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants.
Recent studies have shown that the transcription factor nuclear factor kappaB (NF-kappaB) regulates critical survival pathways in… 
2004
2004
The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta.
2004
2004
Proteasome inhibition induces cytokeratin accumulation in vivo.
Highly Cited
2003
Highly Cited
2003
Differential Apoptotic Response to the Proteasome Inhibitor Bortezomib (VELCADETM, PS-341) in Bax-Deficient and p21-Deficient Colon Cancer Cells
Targeting the ubiquitin-proteasome pathway has emerged as a promising approach for treating cancer. Bortezomib (VELCADETM… 
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