PS 341

Known as: 341, PS, PS-341, PS341 
 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
We have recently shown that proteasome inhibitor PS-341 induces apoptosis in drug-resistant multiple myeloma (MM) cells, inhibits… (More)
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Highly Cited
2003
Highly Cited
2003
The proteasome inhibitor PS-341 inhibits nuclear factor-kappaB (NF-kappaB) activation, induces apoptosis in cancer cells… (More)
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Highly Cited
2003
Highly Cited
2003
Increased nuclear factor kappaB (NF-kappaB) activity is associated with increased tumor cell survival in multiple myeloma. The… (More)
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Highly Cited
2003
Highly Cited
2003
Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action… (More)
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Highly Cited
2002
Highly Cited
2002
The proteasome is a ubiquitous and essential intracellular enzyme that degrades many proteins regulating cell cycle, apoptosis… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacodynamics (PD) of the proteasome… (More)
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Highly Cited
2001
Highly Cited
2001
Human multiple myeloma (MM) is a presently incurable hematological malignancy, and novel biologically based therapies are… (More)
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Highly Cited
2001
Highly Cited
2001
Inducible activation of nuclear factor-kappaB (NF-kappaB) inhibits the apoptotic response to chemotherapy and irradiation… (More)
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Highly Cited
2001
Highly Cited
2001
We have shown that activation of nuclear factor-kappa B (NF-kappa B) promotes cell survival and expression of cytokines such as… (More)
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Highly Cited
1999
Highly Cited
1999
The anticancer activity of the boronic acid dipeptide proteasome inhibitor PS-341 was examined in vitro and in vivo. PS-341 was a… (More)
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